Koelsch G - Search Results

1

Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase).

Ghosh AK, Shin D, Downs D, Koelsch G, Lin X, Ermolieff J, Tang J. Ghosh AK, et al. Among authors: koelsch g. J Am Chem Soc. 2000 Apr 12;122(14):3522-3523. doi: 10.1021/ja000300g. Epub 2000 Mar 23. J Am Chem Soc. 2000. PMID: 30443047 Free PMC article. No abstract available.

2

Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity.

Turner RT 3rd, Loy JA, Nguyen C, Devasamudram T, Ghosh AK, Koelsch G, Tang J. Turner RT 3rd, et al. Among authors: koelsch g. Biochemistry. 2002 Jul 9;41(27):8742-6. doi: 10.1021/bi025926t. Biochemistry. 2002. PMID: 12093293

3

Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3.

Hong L, Turner RT 3rd, Koelsch G, Shin D, Ghosh AK, Tang J. Hong L, et al. Among authors: koelsch g. Biochemistry. 2002 Sep 10;41(36):10963-7. doi: 10.1021/bi026232n. Biochemistry. 2002. PMID: 12206667

4

Study of memapsin 2 (beta-secretase) and strategy of inhibitor design.

Tang J, Ghosh AK, Hong L, Koelsch G, Turner RT 3rd, Chang W. Tang J, et al. Among authors: koelsch g. J Mol Neurosci. 2003;20(3):299-304. doi: 10.1385/JMN:20:3:299. J Mol Neurosci. 2003. PMID: 14501012 Review.

5

Memapsin 2, a drug target for Alzheimer's disease.

Koelsch G, Turner RT 3rd, Hong L, Ghosh AK, Tang J. Koelsch G, et al. Biochem Soc Symp. 2003;(70):213-20. doi: 10.1042/bss0700213. Biochem Soc Symp. 2003. PMID: 14587294 Review.

6

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors.

Chang WP, Koelsch G, Wong S, Downs D, Da H, Weerasena V, Gordon B, Devasamudram T, Bilcer G, Ghosh AK, Tang J. Chang WP, et al. Among authors: koelsch g. J Neurochem. 2004 Jun;89(6):1409-16. doi: 10.1111/j.1471-4159.2004.02452.x. J Neurochem. 2004. PMID: 15189343 Free article.

7

Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase).

Turner RT 3rd, Hong L, Koelsch G, Ghosh AK, Tang J. Turner RT 3rd, et al. Among authors: koelsch g. Biochemistry. 2005 Jan 11;44(1):105-12. doi: 10.1021/bi048106k. Biochemistry. 2005. PMID: 15628850

8

Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors.

Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Ghosh AK, et al. Among authors: koelsch g. J Am Chem Soc. 2006 Apr 26;128(16):5310-1. doi: 10.1021/ja058636j. J Am Chem Soc. 2006. PMID: 16620080 Free PMC article.

9

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.

Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J. Lin X, et al. Among authors: koelsch g. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1456-60. doi: 10.1073/pnas.97.4.1456. Proc Natl Acad Sci U S A. 2000. PMID: 10677483 Free PMC article.

10

Proteolytic activation of recombinant pro-memapsin 2 (pro-beta-secretase) studied with new fluorogenic substrates.

Ermolieff J, Loy JA, Koelsch G, Tang J. Ermolieff J, et al. Among authors: koelsch g. Biochemistry. 2000 Oct 10;39(40):12450-6. doi: 10.1021/bi001494f. Biochemistry. 2000. PMID: 11015226

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

48 results

Search Page