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Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors.
Tsolakos N, Durrant TN, Chessa T, Suire SM, Oxley D, Kulkarni S, Downward J, Perisic O, Williams RL, Stephens L, Hawkins PT. Tsolakos N, et al. Among authors: downward j. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12176-12181. doi: 10.1073/pnas.1803446115. Epub 2018 Nov 15. Proc Natl Acad Sci U S A. 2018. PMID: 30442661 Free PMC article.
Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.
Mathew G, Hannan A, Hertzler-Schaefer K, Wang F, Feng GS, Zhong J, Zhao JJ, Downward J, Zhang X. Mathew G, et al. Among authors: downward j. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13156-13161. doi: 10.1073/pnas.1604450113. Epub 2016 Oct 31. Proc Natl Acad Sci U S A. 2016. PMID: 27799550 Free PMC article.
P110delta, a novel phosphoinositide 3-kinase in leukocytes.
Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD. Vanhaesebroeck B, et al. Among authors: downward j. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4330-5. doi: 10.1073/pnas.94.9.4330. Proc Natl Acad Sci U S A. 1997. PMID: 9113989 Free PMC article.
Chromosomal instability determines taxane response.
Swanton C, Nicke B, Schuett M, Eklund AC, Ng C, Li Q, Hardcastle T, Lee A, Roy R, East P, Kschischo M, Endesfelder D, Wylie P, Kim SN, Chen JG, Howell M, Ried T, Habermann JK, Auer G, Brenton JD, Szallasi Z, Downward J. Swanton C, et al. Among authors: downward j. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8671-6. doi: 10.1073/pnas.0811835106. Epub 2009 May 19. Proc Natl Acad Sci U S A. 2009. PMID: 19458043 Free PMC article.
Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α.
Ismail M, Martin SR, George R, Houghton F, Kelly G, Chaleil RAG, Anastasiou P, Wang X, O'Reilly N, Federico S, Joshi D, Nagaraj H, Cooley R, Hui NS, Molina-Arcas M, Hancock DC, Tavassoli A, Downward J. Ismail M, et al. Among authors: downward j. Sci Rep. 2023 Feb 2;13(1):1889. doi: 10.1038/s41598-023-28756-0. Sci Rep. 2023. PMID: 36732563 Free PMC article.
SnapShot: Ras Signaling.
Cully M, Downward J. Cully M, et al. Among authors: downward j. Cell. 2008 Jun 27;133(7):1292-1292.e1. doi: 10.1016/j.cell.2008.06.020. Cell. 2008. PMID: 18585361 Free article. No abstract available.
296 results