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P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition.
Vázquez-Rosa E, Shin MK, Dhar M, Chaubey K, Cintrón-Pérez CJ, Tang X, Liao X, Miller E, Koh Y, Barker S, Franke K, Crosby DR, Schroeder R, Emery J, Yin TC, Fujioka H, Reynolds JD, Harper MM, Jain MK, Pieper AA. Vázquez-Rosa E, et al. Among authors: pieper aa. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27667-27675. doi: 10.1073/pnas.2010430117. Epub 2020 Oct 21. Proc Natl Acad Sci U S A. 2020. PMID: 33087571 Free PMC article.
Reducing acetylated tau is neuroprotective in brain injury.
Shin MK, Vázquez-Rosa E, Koh Y, Dhar M, Chaubey K, Cintrón-Pérez CJ, Barker S, Miller E, Franke K, Noterman MF, Seth D, Allen RS, Motz CT, Rao SR, Skelton LA, Pardue MT, Fliesler SJ, Wang C, Tracy TE, Gan L, Liebl DJ, Savarraj JPJ, Torres GL, Ahnstedt H, McCullough LD, Kitagawa RS, Choi HA, Zhang P, Hou Y, Chiang CW, Li L, Ortiz F, Kilgore JA, Williams NS, Whitehair VC, Gefen T, Flanagan ME, Stamler JS, Jain MK, Kraus A, Cheng F, Reynolds JD, Pieper AA. Shin MK, et al. Among authors: pieper aa. Cell. 2021 May 13;184(10):2715-2732.e23. doi: 10.1016/j.cell.2021.03.032. Epub 2021 Apr 13. Cell. 2021. PMID: 33852912 Free PMC article.
(-)-P7C3-S243 Protects a Rat Model of Alzheimer's Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia.
Voorhees JR, Remy MT, Cintrón-Pérez CJ, El Rassi E, Khan MZ, Dutca LM, Yin TC, McDaniel LN, Williams NS, Brat DJ, Pieper AA. Voorhees JR, et al. Among authors: pieper aa. Biol Psychiatry. 2018 Oct 1;84(7):488-498. doi: 10.1016/j.biopsych.2017.10.023. Epub 2017 Nov 6. Biol Psychiatry. 2018. PMID: 29246437 Free PMC article.
Ca2+-Binding Protein 1 Regulates Hippocampal-dependent Memory and Synaptic Plasticity.
Yang T, Britt JK, Cintrón-Pérez CJ, Vázquez-Rosa E, Tobin KV, Stalker G, Hardie J, Taugher RJ, Wemmie J, Pieper AA, Lee A. Yang T, et al. Among authors: pieper aa. Neuroscience. 2018 Jun 1;380:90-102. doi: 10.1016/j.neuroscience.2018.04.004. Epub 2018 Apr 14. Neuroscience. 2018. PMID: 29660444 Free PMC article.
Neuroprotective efficacy of P7C3 compounds in primate hippocampus.
Bauman MD, Schumann CM, Carlson EL, Taylor SL, Vázquez-Rosa E, Cintrón-Pérez CJ, Shin MK, Williams NS, Pieper AA. Bauman MD, et al. Among authors: pieper aa. Transl Psychiatry. 2018 Sep 26;8(1):202. doi: 10.1038/s41398-018-0244-1. Transl Psychiatry. 2018. PMID: 30258178 Free PMC article.
124 results