Harris RS - Search Results

1

Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2'-Deoxyzebularine Analogues.

Kvach MV, Barzak FM, Harjes S, Schares HAM, Jameson GB, Ayoub AM, Moorthy R, Aihara H, Harris RS, Filichev VV, Harki DA, Harjes E. Kvach MV, et al. Among authors: harris rs. Biochemistry. 2019 Feb 5;58(5):391-400. doi: 10.1021/acs.biochem.8b00858. Epub 2018 Nov 28. Biochemistry. 2019. PMID: 30418757 Free PMC article.

2

Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G.

Chen KM, Harjes E, Gross PJ, Fahmy A, Lu Y, Shindo K, Harris RS, Matsuo H. Chen KM, et al. Among authors: harris rs. Nature. 2008 Mar 6;452(7183):116-9. doi: 10.1038/nature06638. Epub 2008 Feb 20. Nature. 2008. PMID: 18288108

3

An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model.

Harjes E, Gross PJ, Chen KM, Lu Y, Shindo K, Nowarski R, Gross JD, Kotler M, Harris RS, Matsuo H. Harjes E, et al. Among authors: harris rs. J Mol Biol. 2009 Jun 26;389(5):819-32. doi: 10.1016/j.jmb.2009.04.031. Epub 2009 Apr 21. J Mol Biol. 2009. PMID: 19389408 Free PMC article.

4

Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces.

Shandilya SM, Nalam MN, Nalivaika EA, Gross PJ, Valesano JC, Shindo K, Li M, Munson M, Royer WE, Harjes E, Kono T, Matsuo H, Harris RS, Somasundaran M, Schiffer CA. Shandilya SM, et al. Among authors: harris rs. Structure. 2010 Jan 13;18(1):28-38. doi: 10.1016/j.str.2009.10.016. Structure. 2010. PMID: 20152150 Free PMC article.

5

A single amino acid in human APOBEC3F alters susceptibility to HIV-1 Vif.

Albin JS, LaRue RS, Weaver JA, Brown WL, Shindo K, Harjes E, Matsuo H, Harris RS. Albin JS, et al. Among authors: harris rs. J Biol Chem. 2010 Dec 24;285(52):40785-92. doi: 10.1074/jbc.M110.173161. Epub 2010 Oct 22. J Biol Chem. 2010. PMID: 20971849 Free PMC article.

6

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.

Li M, Shandilya SM, Carpenter MA, Rathore A, Brown WL, Perkins AL, Harki DA, Solberg J, Hook DJ, Pandey KK, Parniak MA, Johnson JR, Krogan NJ, Somasundaran M, Ali A, Schiffer CA, Harris RS. Li M, et al. Among authors: harris rs. ACS Chem Biol. 2012 Mar 16;7(3):506-17. doi: 10.1021/cb200440y. Epub 2012 Jan 17. ACS Chem Biol. 2012. PMID: 22181350 Free PMC article.

7

Nanoscale structure and dynamics of ABOBEC3G complexes with single-stranded DNA.

Shlyakhtenko LS, Lushnikov AY, Miyagi A, Li M, Harris RS, Lyubchenko YL. Shlyakhtenko LS, et al. Among authors: harris rs. Biochemistry. 2012 Aug 14;51(32):6432-40. doi: 10.1021/bi300733d. Epub 2012 Jul 31. Biochemistry. 2012. PMID: 22809226 Free PMC article.

8

Small-molecule APOBEC3G DNA cytosine deaminase inhibitors based on a 4-amino-1,2,4-triazole-3-thiol scaffold.

Olson ME, Li M, Harris RS, Harki DA. Olson ME, et al. Among authors: harris rs. ChemMedChem. 2013 Jan;8(1):112-7. doi: 10.1002/cmdc.201200411. Epub 2012 Nov 23. ChemMedChem. 2013. PMID: 23180603 Free PMC article.

9

Dispersed sites of HIV Vif-dependent polyubiquitination in the DNA deaminase APOBEC3F.

Albin JS, Anderson JS, Johnson JR, Harjes E, Matsuo H, Krogan NJ, Harris RS. Albin JS, et al. Among authors: harris rs. J Mol Biol. 2013 Apr 12;425(7):1172-82. doi: 10.1016/j.jmb.2013.01.010. Epub 2013 Jan 11. J Mol Biol. 2013. PMID: 23318957 Free PMC article.

10

Impact of H216 on the DNA binding and catalytic activities of the HIV restriction factor APOBEC3G.

Harjes S, Solomon WC, Li M, Chen KM, Harjes E, Harris RS, Matsuo H. Harjes S, et al. Among authors: harris rs. J Virol. 2013 Jun;87(12):7008-14. doi: 10.1128/JVI.03173-12. Epub 2013 Apr 17. J Virol. 2013. PMID: 23596292 Free PMC article.

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