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Analysis of the impact of controlled release formulations on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model.
Olivares-Morales A, Kamiyama Y, Darwich AS, Aarons L, Rostami-Hodjegan A. Olivares-Morales A, et al. Among authors: darwich as. Eur J Pharm Sci. 2015 Jan 25;67:32-44. doi: 10.1016/j.ejps.2014.10.018. Epub 2014 Nov 5. Eur J Pharm Sci. 2015. PMID: 25444842 Free article.
Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1-OH-midazolam in morbidly obese and weight loss surgery patients.
Brill MJ, Välitalo PA, Darwich AS, van Ramshorst B, van Dongen HP, Rostami-Hodjegan A, Danhof M, Knibbe CA. Brill MJ, et al. Among authors: darwich as. CPT Pharmacometrics Syst Pharmacol. 2016 Jan;5(1):20-30. doi: 10.1002/psp4.12048. Epub 2015 Dec 18. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 26844012 Free PMC article.
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