Kang TH - Search Results

1

Farewell to Animal Testing: Innovations on Human Intestinal Microphysiological Systems.

Kang TH, Kim HJ. Kang TH, et al. Micromachines (Basel). 2016 Jun 27;7(7):107. doi: 10.3390/mi7070107. Micromachines (Basel). 2016. PMID: 30404281 Free PMC article. Review.

2

Revisiting the role of glycosylation in the structure of human IgG Fc.

Borrok MJ, Jung ST, Kang TH, Monzingo AF, Georgiou G. Borrok MJ, et al. Among authors: kang th. ACS Chem Biol. 2012 Sep 21;7(9):1596-602. doi: 10.1021/cb300130k. Epub 2012 Jul 10. ACS Chem Biol. 2012. PMID: 22747430 Free PMC article.

3

Bypassing glycosylation: engineering aglycosylated full-length IgG antibodies for human therapy.

Jung ST, Kang TH, Kelton W, Georgiou G. Jung ST, et al. Among authors: kang th. Curr Opin Biotechnol. 2011 Dec;22(6):858-67. doi: 10.1016/j.copbio.2011.03.002. Epub 2011 Mar 21. Curr Opin Biotechnol. 2011. PMID: 21420850 Review.

4

Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity.

Jung ST, Kelton W, Kang TH, Ng DT, Andersen JT, Sandlie I, Sarkar CA, Georgiou G. Jung ST, et al. Among authors: kang th. ACS Chem Biol. 2013 Feb 15;8(2):368-75. doi: 10.1021/cb300455f. Epub 2012 Oct 11. ACS Chem Biol. 2013. PMID: 23030766

5

Efficient expression and purification of human aglycosylated Fcgamma receptors in Escherichia coli.

Jung ST, Kang TH, Georgiou G. Jung ST, et al. Among authors: kang th. Biotechnol Bioeng. 2010 Sep 1;107(1):21-30. doi: 10.1002/bit.22785. Biotechnol Bioeng. 2010. PMID: 20506277

6

Comprehensive engineering of Escherichia coli for enhanced expression of IgG antibodies.

Makino T, Skretas G, Kang TH, Georgiou G. Makino T, et al. Among authors: kang th. Metab Eng. 2011 Mar;13(2):241-51. doi: 10.1016/j.ymben.2010.11.002. Epub 2010 Dec 3. Metab Eng. 2011. PMID: 21130896 Free PMC article.

7

IgGA: a "cross-isotype" engineered human Fc antibody domain that displays both IgG-like and IgA-like effector functions.

Kelton W, Mehta N, Charab W, Lee J, Lee CH, Kojima T, Kang TH, Georgiou G. Kelton W, et al. Among authors: kang th. Chem Biol. 2014 Dec 18;21(12):1603-9. doi: 10.1016/j.chembiol.2014.10.017. Epub 2014 Dec 11. Chem Biol. 2014. PMID: 25500223

8

Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells.

Jung ST, Reddy ST, Kang TH, Borrok MJ, Sandlie I, Tucker PW, Georgiou G. Jung ST, et al. Among authors: kang th. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):604-9. doi: 10.1073/pnas.0908590107. Epub 2009 Dec 18. Proc Natl Acad Sci U S A. 2010. PMID: 20080725 Free PMC article.

9

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence.

Lee CH, Kang TH, Godon O, Watanabe M, Delidakis G, Gillis CM, Sterlin D, Hardy D, Cogné M, Macdonald LE, Murphy AJ, Tu N, Lee J, McDaniel JR, Makowski E, Tessier PM, Meyer AS, Bruhns P, Georgiou G. Lee CH, et al. Among authors: kang th. Nat Commun. 2019 Nov 6;10(1):5031. doi: 10.1038/s41467-019-13108-2. Nat Commun. 2019. PMID: 31695028 Free PMC article.

10

An Engineered Human Fc variant With Exquisite Selectivity for FcγRIIIa_V158 Reveals That Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis With GM-CSF-Differentiated Macrophages.

Kang TH, Lee CH, Delidakis G, Jung J, Richard-Le Goff O, Lee J, Kim JE, Charab W, Bruhns P, Georgiou G. Kang TH, et al. Front Immunol. 2019 Mar 27;10:562. doi: 10.3389/fimmu.2019.00562. eCollection 2019. Front Immunol. 2019. PMID: 30984171 Free PMC article.

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