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Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment.
Abdul-Aziz AM, Sun Y, Hellmich C, Marlein CR, Mistry J, Forde E, Piddock RE, Shafat MS, Morfakis A, Mehta T, Di Palma F, Macaulay I, Ingham CJ, Haestier A, Collins A, Campisi J, Bowles KM, Rushworth SA. Abdul-Aziz AM, et al. Among authors: shafat ms. Blood. 2019 Jan 31;133(5):446-456. doi: 10.1182/blood-2018-04-845420. Epub 2018 Nov 6. Blood. 2019. PMID: 30401703 Free PMC article.
Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.
Shafat MS, Oellerich T, Mohr S, Robinson SD, Edwards DR, Marlein CR, Piddock RE, Fenech M, Zaitseva L, Abdul-Aziz A, Turner J, Watkins JA, Lawes M, Bowles KM, Rushworth SA. Shafat MS, et al. Blood. 2017 Mar 9;129(10):1320-1332. doi: 10.1182/blood-2016-08-734798. Epub 2017 Jan 3. Blood. 2017. PMID: 28049638 Free article.
Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML.
Zaitseva L, Murray MY, Shafat MS, Lawes MJ, MacEwan DJ, Bowles KM, Rushworth SA. Zaitseva L, et al. Among authors: shafat ms. Oncotarget. 2014 Oct 30;5(20):9930-8. doi: 10.18632/oncotarget.2479. Oncotarget. 2014. PMID: 25294819 Free PMC article.
Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells.
Rushworth SA, Pillinger G, Abdul-Aziz A, Piddock R, Shafat MS, Murray MY, Zaitseva L, Lawes MJ, MacEwan DJ, Bowles KM. Rushworth SA, et al. Among authors: shafat ms. Lancet Haematol. 2015 May;2(5):e204-11. doi: 10.1016/S2352-3026(15)00046-0. Epub 2015 Apr 14. Lancet Haematol. 2015. PMID: 26688095
20 results