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Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid.
Kortagere S, Madani N, Mankowski MK, Schön A, Zentner I, Swaminathan G, Princiotto A, Anthony K, Oza A, Sierra LJ, Passic SR, Wang X, Jones DM, Stavale E, Krebs FC, Martín-García J, Freire E, Ptak RG, Sodroski J, Cocklin S, Smith AB 3rd. Kortagere S, et al. Among authors: ptak rg. J Virol. 2012 Aug;86(16):8472-81. doi: 10.1128/JVI.05006-11. Epub 2012 May 30. J Virol. 2012. PMID: 22647699 Free PMC article.
Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.
Zentner I, Sierra LJ, Maciunas L, Vinnik A, Fedichev P, Mankowski MK, Ptak RG, Martín-García J, Cocklin S. Zentner I, et al. Among authors: ptak rg. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1132-5. doi: 10.1016/j.bmcl.2012.11.041. Epub 2012 Nov 29. Bioorg Med Chem Lett. 2013. PMID: 23305922 Free PMC article.
Identification of a small-molecule inhibitor of HIV-1 assembly that targets the phosphatidylinositol (4,5)-bisphosphate binding site of the HIV-1 matrix protein.
Zentner I, Sierra LJ, Fraser AK, Maciunas L, Mankowski MK, Vinnik A, Fedichev P, Ptak RG, Martín-García J, Cocklin S. Zentner I, et al. Among authors: ptak rg. ChemMedChem. 2013 Mar;8(3):426-32. doi: 10.1002/cmdc.201200577. Epub 2013 Jan 29. ChemMedChem. 2013. PMID: 23361947 Free PMC article.
An analog of camptothecin inactive against Topoisomerase I is broadly neutralizing of HIV-1 through inhibition of Vif-dependent APOBEC3G degradation.
Bennett RP, Stewart RA, Hogan PA, Ptak RG, Mankowski MK, Hartman TL, Buckheit RW Jr, Snyder BA, Salter JD, Morales GA, Smith HC. Bennett RP, et al. Among authors: ptak rg. Antiviral Res. 2016 Dec;136:51-59. doi: 10.1016/j.antiviral.2016.11.001. Epub 2016 Nov 5. Antiviral Res. 2016. PMID: 27825797 Free PMC article.
Potent strategy to inhibit HIV-1 by binding both gp120 and gp41.
Kagiampakis I, Gharibi A, Mankowski MK, Snyder BA, Ptak RG, Alatas K, LiWang PJ. Kagiampakis I, et al. Among authors: ptak rg. Antimicrob Agents Chemother. 2011 Jan;55(1):264-75. doi: 10.1128/AAC.00376-10. Epub 2010 Oct 18. Antimicrob Agents Chemother. 2011. PMID: 20956603 Free PMC article.
Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement.
Tuyishime M, Danish M, Princiotto A, Mankowski MK, Lawrence R, Lombart HG, Esikov K, Berniac J, Liang K, Ji J, Ptak RG, Madani N, Cocklin S. Tuyishime M, et al. Among authors: ptak rg. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5439-45. doi: 10.1016/j.bmcl.2014.10.027. Bioorg Med Chem Lett. 2014. PMID: 25454268 Free PMC article.
93 results