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Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs.
Sahoo BR , Genjo T , Bekier M , Cox SJ , Stoddard AK , Ivanova M , Yasuhara K , Fierke CA , Wang Y , Ramamoorthy A . Sahoo BR , et al. Among authors: cox sj. Chem Commun (Camb). 2018 Nov 13;54(91):12883-12886. doi: 10.1039/c8cc07921h. Chem Commun (Camb). 2018. PMID: 30379172 Free PMC article.
Zinc boosts EGCG's hIAPP amyloid Inhibition both in solution and membrane.
Lee YH, Lin Y, Cox SJ, Kinoshita M, Sahoo BR, Ivanova M, Ramamoorthy A. Lee YH, et al. Among authors: cox sj. Biochim Biophys Acta Proteins Proteom. 2019 May;1867(5):529-536. doi: 10.1016/j.bbapap.2018.11.006. Epub 2018 Nov 22. Biochim Biophys Acta Proteins Proteom. 2019. PMID: 30468883 Free PMC article.
Small molecule induced toxic human-IAPP species characterized by NMR.
Cox SJ , Rodriguez Camargo DC , Lee YH , Dubini RCA , Rovó P , Ivanova MI , Padmini V , Reif B , Ramamoorthy A . Cox SJ , et al. Chem Commun (Camb). 2020 Nov 7;56(86):13129-13132. doi: 10.1039/d0cc04803h. Epub 2020 Oct 2. Chem Commun (Camb). 2020. PMID: 33006345 Free PMC article.
Formation of pH-Resistant Monodispersed Polymer-Lipid Nanodiscs.
Ravula T, Hardin NZ, Ramadugu SK, Cox SJ, Ramamoorthy A. Ravula T, et al. Among authors: cox sj. Angew Chem Int Ed Engl. 2018 Jan 26;57(5):1342-1345. doi: 10.1002/anie.201712017. Epub 2018 Jan 8. Angew Chem Int Ed Engl. 2018. PMID: 29232017 Free PMC article.
hIAPP forms toxic oligomers in plasma.
Rodriguez Camargo DC , Garg D , Buday K , Franko A , Rodriguez Camargo A , Schmidt F , Cox SJ , Suladze S , Haslbeck M , Mideksa YG , Gemmecker G , Aichler M , Mettenleiter G , Schulz M , Walch AK , Hrabě de Angelis M , Feige MJ , Sierra CA , Conrad M , Tripsianes K , Ramamoorthy A , Reif B . Rodriguez Camargo DC , et al. Among authors: cox sj. Chem Commun (Camb). 2018 May 24;54(43):5426-5429. doi: 10.1039/c8cc03097a. Chem Commun (Camb). 2018. PMID: 29745410 Free PMC article.
177 results