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Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory.
Viaud S, Ma JSY, Hardy IR, Hampton EN, Benish B, Sherwood L, Nunez V, Ackerman CJ, Khialeeva E, Weglarz M, Lee SC, Woods AK, Young TS. Viaud S, et al. Among authors: hardy ir. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10898-E10906. doi: 10.1073/pnas.1810060115. Epub 2018 Oct 29. Proc Natl Acad Sci U S A. 2018. PMID: 30373813 Free PMC article.
Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies.
Rodgers DT, Mazagova M, Hampton EN, Cao Y, Ramadoss NS, Hardy IR, Schulman A, Du J, Wang F, Singer O, Ma J, Nunez V, Shen J, Woods AK, Wright TM, Schultz PG, Kim CH, Young TS. Rodgers DT, et al. Among authors: hardy ir. Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):E459-68. doi: 10.1073/pnas.1524155113. Epub 2016 Jan 12. Proc Natl Acad Sci U S A. 2016. PMID: 26759369 Free PMC article.
Anti-CD79 antibody induces B cell anergy that protects against autoimmunity.
Hardy IR, Anceriz N, Rousseau F, Seefeldt MB, Hatterer E, Irla M, Buatois V, Chatel LE, Getahun A, Fletcher A, Cons L, Pontini G, Hertzberg NA, Magistrelli G, Malinge P, Smith MJ, Reith W, Kosco-Vilbois MH, Ferlin WG, Cambier JC. Hardy IR, et al. J Immunol. 2014 Feb 15;192(4):1641-50. doi: 10.4049/jimmunol.1302672. Epub 2014 Jan 17. J Immunol. 2014. PMID: 24442438 Free PMC article.
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