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Myostatin and activin blockade by engineered follistatin results in hypertrophy and improves dystrophic pathology in mdx mouse more than myostatin blockade alone.
Iskenderian A, Liu N, Deng Q, Huang Y, Shen C, Palmieri K, Crooker R, Lundberg D, Kastrapeli N, Pescatore B, Romashko A, Dumas J, Comeau R, Norton A, Pan J, Rong H, Derakhchan K, Ehmann DE. Iskenderian A, et al. Among authors: romashko a. Skelet Muscle. 2018 Oct 27;8(1):34. doi: 10.1186/s13395-018-0180-z. Skelet Muscle. 2018. PMID: 30368252 Free PMC article.
Protein Engineering on Human Recombinant Follistatin: Enhancing Pharmacokinetic Characteristics for Therapeutic Application.
Shen C, Iskenderian A, Lundberg D, He T, Palmieri K, Crooker R, Deng Q, Traylor M, Gu S, Rong H, Ehmann D, Pescatore B, Strack-Logue B, Romashko A, Baviello G, Gill J, Zhang B, Meiyappan M, Pan C, Norton AW. Shen C, et al. Among authors: romashko a. J Pharmacol Exp Ther. 2018 Aug;366(2):291-302. doi: 10.1124/jpet.118.248195. Epub 2018 May 11. J Pharmacol Exp Ther. 2018. PMID: 29752426
SRD005825 Acts as a Pharmacologic Chaperone of Opsin and Promotes Survival of Photoreceptors in an Animal Model of Autosomal Dominant Retinitis Pigmentosa.
Ahmed CM, Dwyer BT, Romashko A, Van Adestine S, Park EH, Lou Z, Welty D, Josiah S, Savinainen A, Zhang B, Lewin AS. Ahmed CM, et al. Among authors: romashko a. Transl Vis Sci Technol. 2019 Dec 12;8(6):30. doi: 10.1167/tvst.8.6.30. eCollection 2019 Nov. Transl Vis Sci Technol. 2019. PMID: 31857914 Free PMC article.
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