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Myostatin and activin blockade by engineered follistatin results in hypertrophy and improves dystrophic pathology in mdx mouse more than myostatin blockade alone.
Iskenderian A, Liu N, Deng Q, Huang Y, Shen C, Palmieri K, Crooker R, Lundberg D, Kastrapeli N, Pescatore B, Romashko A, Dumas J, Comeau R, Norton A, Pan J, Rong H, Derakhchan K, Ehmann DE. Iskenderian A, et al. Among authors: huang y. Skelet Muscle. 2018 Oct 27;8(1):34. doi: 10.1186/s13395-018-0180-z. Skelet Muscle. 2018. PMID: 30368252 Free PMC article.
VEGFR-1/Flt-1 inhibition increases angiogenesis and improves muscle function in a mouse model of Duchenne muscular dystrophy.
Bosco J, Zhou Z, Gabriëls S, Verma M, Liu N, Miller BK, Gu S, Lundberg DM, Huang Y, Brown E, Josiah S, Meiyappan M, Traylor MJ, Chen N, Asakura A, De Jonge N, Blanchetot C, de Haard H, Duffy HS, Keefe D. Bosco J, et al. Among authors: huang y. Mol Ther Methods Clin Dev. 2021 Mar 23;21:369-381. doi: 10.1016/j.omtm.2021.03.013. eCollection 2021 Jun 11. Mol Ther Methods Clin Dev. 2021. PMID: 33898634 Free PMC article.
Gene therapy for cross-correction of somatic organs and the CNS in mucopolysaccharidosis II in rodents and non-human primates.
Chen N, Ehmann DE, Crooker R, Derakhchan K, Fang X, Felice B, Galbreath EJ, Glaus C, Gu H, Huang Y, Li C, Li X, Liu N, Palmieri K, Simic D, Sypek J, Thompson S, Winkelmann CT, Choi VW. Chen N, et al. Among authors: huang y. Mol Ther Methods Clin Dev. 2023 Mar 28;29:286-302. doi: 10.1016/j.omtm.2023.03.014. eCollection 2023 Jun 8. Mol Ther Methods Clin Dev. 2023. PMID: 37359415 Free PMC article.
Intravenously Administered Recombinant Human Type VII Collagen Derived from Chinese Hamster Ovary Cells Reverses the Disease Phenotype in Recessive Dystrophic Epidermolysis Bullosa Mice.
Hou Y, Guey LT, Wu T, Gao R, Cogan J, Wang X, Hong E, Vivian Ning W, Keene D, Liu N, Huang Y, Kaftan C, Tangarone B, Quinones-Garcia I, Uitto J, Francone OL, Woodley DT, Chen M. Hou Y, et al. Among authors: huang y. J Invest Dermatol. 2015 Dec;135(12):3060-3067. doi: 10.1038/jid.2015.291. Epub 2015 Jul 23. J Invest Dermatol. 2015. PMID: 26203639 Free article.
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