Morrill C - Search Results

1

The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential.

Friesen WJ, Johnson B, Sierra J, Zhuo J, Vazirani P, Xue X, Tomizawa Y, Baiazitov R, Morrill C, Ren H, Babu S, Moon YC, Branstrom A, Mollin A, Hedrick J, Sheedy J, Elfring G, Weetall M, Colacino JM, Welch EM, Peltz SW. Friesen WJ, et al. Among authors: morrill c. PLoS One. 2018 Oct 25;13(10):e0206158. doi: 10.1371/journal.pone.0206158. eCollection 2018. PLoS One. 2018. PMID: 30359426 Free PMC article.

2

Guanidino quinazolines and pyrimidines promote readthrough of premature termination codons in cells with native nonsense mutations.

Morrill C, Friesen WJ, Babu S, Baiazitov RY, Du W, Karloff DB, Lee CS, Moon YC, Ren H, Sierra J, Tomizawa Y, Vazirani P, Welch EM, Xue X, Zhuo J. Morrill C, et al. Bioorg Med Chem Lett. 2022 Nov 15;76:128989. doi: 10.1016/j.bmcl.2022.128989. Epub 2022 Sep 20. Bioorg Med Chem Lett. 2022. PMID: 36150638

3

Selective synthesis of 1-substituted 4-chloropyrazolo[3,4-d]pyrimidines.

Babu S, Morrill C, Almstead NG, Moon YC. Babu S, et al. Among authors: morrill c. Org Lett. 2013 Apr 19;15(8):1882-5. doi: 10.1021/ol4005382. Epub 2013 Apr 10. Org Lett. 2013. PMID: 23574146

4

Structure-activity relationship (SAR) optimization of 6-(indol-2-yl)pyridine-3-sulfonamides: identification of potent, selective, and orally bioavailable small molecules targeting hepatitis C (HCV) NS4B.

Zhang N, Zhang X, Zhu J, Turpoff A, Chen G, Morrill C, Huang S, Lennox W, Kakarla R, Liu R, Li C, Ren H, Almstead N, Venkatraman S, Njoroge FG, Gu Z, Clausen V, Graci J, Jung SP, Zheng Y, Colacino JM, Lahser F, Sheedy J, Mollin A, Weetall M, Nomeir A, Karp GM. Zhang N, et al. Among authors: morrill c. J Med Chem. 2014 Mar 13;57(5):2121-35. doi: 10.1021/jm401621g. Epub 2013 Dec 4. J Med Chem. 2014. PMID: 24266880

5

Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B.

Zhang X, Zhang N, Chen G, Turpoff A, Ren H, Takasugi J, Morrill C, Zhu J, Li C, Lennox W, Paget S, Liu Y, Almstead N, Njoroge FG, Gu Z, Komatsu T, Clausen V, Espiritu C, Graci J, Colacino J, Lahser F, Risher N, Weetall M, Nomeir A, Karp GM. Zhang X, et al. Among authors: morrill c. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3947-53. doi: 10.1016/j.bmcl.2013.04.049. Epub 2013 Apr 30. Bioorg Med Chem Lett. 2013. PMID: 23683597

6

Selective ring opening cross metathesis of cyclooctadiene and trisubstituted cycloolefins.

Morgan JP, Morrill C, Grubbs RH. Morgan JP, et al. Among authors: morrill c. Org Lett. 2002 Jan 10;4(1):67-70. doi: 10.1021/ol016918s. Org Lett. 2002. PMID: 11772092

7

Synthesis of 4-arylpiperidines from 1-benzyl-4-piperidone: application of the Shapiro reaction and alkenylsilane cross-coupling.

Morrill C, Mani NS. Morrill C, et al. Org Lett. 2007 Apr 12;9(8):1505-8. doi: 10.1021/ol070241c. Epub 2007 Mar 16. Org Lett. 2007. PMID: 17362023

8

Synthesis of functionalized vinyl boronates via ruthenium-catalyzed olefin cross-metathesis and subsequent conversion to vinyl halides.

Morrill C, Grubbs RH. Morrill C, et al. J Org Chem. 2003 Jul 25;68(15):6031-4. doi: 10.1021/jo0345345. J Org Chem. 2003. PMID: 12868943

9

Highly selective 1,3-isomerization of allylic alcohols via rhenium oxo catalysis.

Morrill C, Grubbs RH. Morrill C, et al. J Am Chem Soc. 2005 Mar 9;127(9):2842-3. doi: 10.1021/ja044054a. J Am Chem Soc. 2005. PMID: 15740106 Free article.

10

Rhenium-catalyzed 1,3-isomerization of allylic alcohols: scope and chirality transfer.

Morrill C, Beutner GL, Grubbs RH. Morrill C, et al. J Org Chem. 2006 Sep 29;71(20):7813-25. doi: 10.1021/jo061436l. J Org Chem. 2006. PMID: 16995691

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