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The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential.
Friesen WJ, Johnson B, Sierra J, Zhuo J, Vazirani P, Xue X, Tomizawa Y, Baiazitov R, Morrill C, Ren H, Babu S, Moon YC, Branstrom A, Mollin A, Hedrick J, Sheedy J, Elfring G, Weetall M, Colacino JM, Welch EM, Peltz SW. Friesen WJ, et al. Among authors: babu s. PLoS One. 2018 Oct 25;13(10):e0206158. doi: 10.1371/journal.pone.0206158. eCollection 2018. PLoS One. 2018. PMID: 30359426 Free PMC article.
The nucleoside analog clitocine is a potent and efficacious readthrough agent.
Friesen WJ, Trotta CR, Tomizawa Y, Zhuo J, Johnson B, Sierra J, Roy B, Weetall M, Hedrick J, Sheedy J, Takasugi J, Moon YC, Babu S, Baiazitov R, Leszyk JD, Davis TW, Colacino JM, Peltz SW, Welch EM. Friesen WJ, et al. Among authors: babu s. RNA. 2017 Apr;23(4):567-577. doi: 10.1261/rna.060236.116. Epub 2017 Jan 17. RNA. 2017. PMID: 28096517 Free PMC article.
Guanidino quinazolines and pyrimidines promote readthrough of premature termination codons in cells with native nonsense mutations.
Morrill C, Friesen WJ, Babu S, Baiazitov RY, Du W, Karloff DB, Lee CS, Moon YC, Ren H, Sierra J, Tomizawa Y, Vazirani P, Welch EM, Xue X, Zhuo J. Morrill C, et al. Among authors: babu s. Bioorg Med Chem Lett. 2022 Nov 15;76:128989. doi: 10.1016/j.bmcl.2022.128989. Epub 2022 Sep 20. Bioorg Med Chem Lett. 2022. PMID: 36150638
Pediatric Trauma.
Hofbauer MH, Babu SS, Bradshaw CL. Hofbauer MH, et al. Among authors: babu ss. Clin Podiatr Med Surg. 2024 Jul;41(3):571-592. doi: 10.1016/j.cpm.2024.02.001. Epub 2024 Mar 19. Clin Podiatr Med Surg. 2024. PMID: 38789171 Review.
Syndesmotic Injuries.
Hofbauer MH, Babu SS. Hofbauer MH, et al. Among authors: babu ss. Clin Podiatr Med Surg. 2024 Jul;41(3):491-502. doi: 10.1016/j.cpm.2024.01.013. Epub 2024 Feb 28. Clin Podiatr Med Surg. 2024. PMID: 38789166 Review.
Lisfranc Injuries.
Hofbauer MH, Babu SS, Vonasek A. Hofbauer MH, et al. Among authors: babu ss. Clin Podiatr Med Surg. 2024 Jul;41(3):407-423. doi: 10.1016/j.cpm.2024.01.014. Epub 2024 Mar 5. Clin Podiatr Med Surg. 2024. PMID: 38789161 Review.
1,656 results