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Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension.
Krishnan SM, Ling YH, Huuskes BM, Ferens DM, Saini N, Chan CT, Diep H, Kett MM, Samuel CS, Kemp-Harper BK, Robertson AAB, Cooper MA, Peter K, Latz E, Mansell AS, Sobey CG, Drummond GR, Vinh A. Krishnan SM, et al. Cardiovasc Res. 2019 Mar 15;115(4):776-787. doi: 10.1093/cvr/cvy252. Cardiovasc Res. 2019. PMID: 30357309 Free PMC article.
IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced Hypertension in Mice.
Thomas JM, Ling YH, Huuskes B, Jelinic M, Sharma P, Saini N, Ferens DM, Diep H, Krishnan SM, Kemp-Harper BK, O'Connor PM, Latz E, Arumugam TV, Guzik TJ, Hickey MJ, Mansell A, Sobey CG, Vinh A, Drummond GR. Thomas JM, et al. Among authors: krishnan sm. Hypertension. 2021 Nov;78(5):1296-1309. doi: 10.1161/HYPERTENSIONAHA.120.16437. Epub 2021 Sep 7. Hypertension. 2021. PMID: 34488433 Free article.
Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice.
Krishnan SM, Dowling JK, Ling YH, Diep H, Chan CT, Ferens D, Kett MM, Pinar A, Samuel CS, Vinh A, Arumugam TV, Hewitson TD, Kemp-Harper BK, Robertson AA, Cooper MA, Latz E, Mansell A, Sobey CG, Drummond GR. Krishnan SM, et al. Br J Pharmacol. 2016 Feb;173(4):752-65. doi: 10.1111/bph.13230. Epub 2015 Jul 31. Br J Pharmacol. 2016. PMID: 26103560 Free PMC article.
M2 macrophage accumulation in the aortic wall during angiotensin II infusion in mice is associated with fibrosis, elastin loss, and elevated blood pressure.
Moore JP, Vinh A, Tuck KL, Sakkal S, Krishnan SM, Chan CT, Lieu M, Samuel CS, Diep H, Kemp-Harper BK, Tare M, Ricardo SD, Guzik TJ, Sobey CG, Drummond GR. Moore JP, et al. Among authors: krishnan sm. Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H906-17. doi: 10.1152/ajpheart.00821.2014. Epub 2015 Jun 12. Am J Physiol Heart Circ Physiol. 2015. PMID: 26071547 Free article.
Obligatory Role for B Cells in the Development of Angiotensin II-Dependent Hypertension.
Chan CT, Sobey CG, Lieu M, Ferens D, Kett MM, Diep H, Kim HA, Krishnan SM, Lewis CV, Salimova E, Tipping P, Vinh A, Samuel CS, Peter K, Guzik TJ, Kyaw TS, Toh BH, Bobik A, Drummond GR. Chan CT, et al. Among authors: krishnan sm. Hypertension. 2015 Nov;66(5):1023-33. doi: 10.1161/HYPERTENSIONAHA.115.05779. Epub 2015 Sep 8. Hypertension. 2015. PMID: 26351030
CD19-CD28: an affinity-optimized CD28 agonist for combination with glofitamab (CD20-TCB) as off-the-shelf immunotherapy.
Sam J, Hofer T, Kuettel C, Claus C, Thom J, Herter S, Georges G, Korfi K, Lechmann M, Eigenmann MJ, Marbach D, Jamois C, Lechner K, Krishnan SM, Gaillard B, Marinho J, Kronenberg S, Kunz L, Wilson S, Briner S, Gebhardt S, Varol A, Appelt B, Nicolini V, Speziale D, Bez M, Bommer E, Eckmann J, Hage C, Limani F, Jenni S, Schoenle A, Le Clech M, Vallier JP, Colombetti S, Bacac M, Gasser S, Klein C, Umaña P. Sam J, et al. Among authors: krishnan sm. Blood. 2024 May 23;143(21):2152-2165. doi: 10.1182/blood.2023023381. Blood. 2024. PMID: 38437725 Free article.
A multistate modeling and simulation framework to learn dose-response of oncology drugs: Application to bintrafusp alfa in non-small cell lung cancer.
Liu H, Milenković-Grišić AM, Krishnan SM, Jönsson S, Friberg LE, Girard P, Venkatakrishnan K, Vugmeyster Y, Khandelwal A, Karlsson MO. Liu H, et al. Among authors: krishnan sm. CPT Pharmacometrics Syst Pharmacol. 2023 Nov;12(11):1738-1750. doi: 10.1002/psp4.12976. Epub 2023 May 11. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37165943 Free PMC article.
72 results