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Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension.
Krishnan SM, Ling YH, Huuskes BM, Ferens DM, Saini N, Chan CT, Diep H, Kett MM, Samuel CS, Kemp-Harper BK, Robertson AAB, Cooper MA, Peter K, Latz E, Mansell AS, Sobey CG, Drummond GR, Vinh A. Krishnan SM, et al. Among authors: huuskes bm. Cardiovasc Res. 2019 Mar 15;115(4):776-787. doi: 10.1093/cvr/cvy252. Cardiovasc Res. 2019. PMID: 30357309 Free PMC article.
Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis.
Pinar AA, Scott TE, Huuskes BM, Tapia Cáceres FE, Kemp-Harper BK, Samuel CS. Pinar AA, et al. Among authors: huuskes bm. Pharmacol Ther. 2020 May;209:107511. doi: 10.1016/j.pharmthera.2020.107511. Epub 2020 Feb 22. Pharmacol Ther. 2020. PMID: 32097669 Review.
IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced Hypertension in Mice.
Thomas JM, Ling YH, Huuskes B, Jelinic M, Sharma P, Saini N, Ferens DM, Diep H, Krishnan SM, Kemp-Harper BK, O'Connor PM, Latz E, Arumugam TV, Guzik TJ, Hickey MJ, Mansell A, Sobey CG, Vinh A, Drummond GR. Thomas JM, et al. Hypertension. 2021 Nov;78(5):1296-1309. doi: 10.1161/HYPERTENSIONAHA.120.16437. Epub 2021 Sep 7. Hypertension. 2021. PMID: 34488433 Free article.
Endothelial Progenitor Cells and Vascular Health in Dialysis Patients.
Huuskes BM, DeBuque RJ, Polkinghorne KR, Samuel CS, Kerr PG, Ricardo SD. Huuskes BM, et al. Kidney Int Rep. 2017 Sep 18;3(1):205-211. doi: 10.1016/j.ekir.2017.09.004. eCollection 2018 Jan. Kidney Int Rep. 2017. PMID: 29340332 Free PMC article. No abstract available.
16 results