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Cytotoxicity of replication-competent adenoviruses powered by an exogenous regulatory region is not linearly correlated with the viral infectivity/gene expression or with the E1A-activating ability but is associated with the p53 genotypes.
Yamauchi S, Zhong B, Kawamura K, Yang S, Kubo S, Shingyoji M, Sekine I, Tada Y, Tatsumi K, Shimada H, Hiroshima K, Tagawa M. Yamauchi S, et al. Among authors: tagawa m. BMC Cancer. 2017 Sep 5;17(1):622. doi: 10.1186/s12885-017-3621-x. BMC Cancer. 2017. PMID: 28874135 Free PMC article.
Replication-competent adenoviruses with the type 35-derived fiber-knob region achieve reactive oxygen species-dependent cytotoxicity and produce greater toxicity than those with the type 5-derived region in pancreatic carcinoma.
Yamauchi S, Kawamura K, Okamoto S, Morinaga T, Jiang Y, Shingyoji M, Sekine I, Kubo S, Tada Y, Tatsumi K, Shimada H, Hiroshima K, Tagawa M. Yamauchi S, et al. Among authors: tagawa m. Apoptosis. 2015 Dec;20(12):1587-98. doi: 10.1007/s10495-015-1171-8. Apoptosis. 2015. PMID: 26373551
771 results