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21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions.
Rocha SC, Pessoa MT, Neves LD, Alves SL, Silva LM, Santos HL, Oliveira SM, Taranto AG, Comar M, Gomes IV, Santos FV, Paixão N, Quintas LE, Noël F, Pereira AF, Tessis AC, Gomes NL, Moreira OC, Rincon-Heredia R, Varotti FP, Blanco G, Villar JA, Contreras RG, Barbosa LA. Rocha SC, et al. Among authors: varotti fp. PLoS One. 2014 Oct 7;9(10):e108776. doi: 10.1371/journal.pone.0108776. eCollection 2014. PLoS One. 2014. PMID: 25290152 Free PMC article.
γ-Benzylidene digoxin derivatives synthesis and molecular modeling: Evaluation of anticancer and the Na,K-ATPase activity effect.
Alves SLG, Paixão N, Ferreira LGR, Santos FRS, Neves LDR, Oliveira GC, Cortes VF, Salomé KS, Barison A, Santos FV, Cenzi G, Varotti FP, Oliveira SMF, Taranto AG, Comar M, Silva LM, Noël F, Quintas LEM, Barbosa LA, Villar JAFP. Alves SLG, et al. Among authors: varotti fp. Bioorg Med Chem. 2015 Aug 1;23(15):4397-4404. doi: 10.1016/j.bmc.2015.06.028. Epub 2015 Jun 17. Bioorg Med Chem. 2015. PMID: 26122772 Free article.
Revealing the Binding Process of New 3-Alkylpyridine Marine Alkaloid Analogue Antimalarials and the Heme Group: An Experimental and Theoretical Investigation.
Ribeiro-Viana RM, Butera AP, Santos ES, Tischer CA, Alves RB, Pereira de Freitas R, Guimarães L, Varotti FP, Viana GH, Nascimento CS Jr. Ribeiro-Viana RM, et al. Among authors: varotti fp. J Chem Inf Model. 2016 Mar 28;56(3):571-9. doi: 10.1021/acs.jcim.5b00742. Epub 2016 Mar 15. J Chem Inf Model. 2016. PMID: 26954429
New bufadienolides extracted from Rhinella marina inhibit Na,K-ATPase and induce apoptosis by activating caspases 3 and 9 in human breast and ovarian cancer cells.
Garcia IJP, de Oliveira GC, de Moura Valadares JM, Banfi FF, Andrade SN, Freitas TR, Dos Santos Monção Filho E, Lima Santos H, Júnior GMV, Chaves MH, de Jesus Rodrigues D, Sanchez BAM, Varotti FP, Barbosa LA. Garcia IJP, et al. Among authors: varotti fp. Steroids. 2019 Dec;152:108490. doi: 10.1016/j.steroids.2019.108490. Epub 2019 Sep 6. Steroids. 2019. PMID: 31499071
Synthesis, antimalarial evaluation and molecular modeling studies of hydroxyethylpiperazines, potential aspartyl protease inhibitors, part 2.
Cunico W, Gomes CR, Facchinetti V, Moreth M, Penido C, Henriques MG, Varotti FP, Krettli LG, Krettli AU, da Silva FS, Caffarena ER, de Magalhães CS. Cunico W, et al. Among authors: varotti fp. Eur J Med Chem. 2009 Sep;44(9):3816-20. doi: 10.1016/j.ejmech.2009.03.041. Epub 2009 Apr 8. Eur J Med Chem. 2009. PMID: 19403210
37 results