Brown AJ - Search Results

1

Whole synthetic pathway engineering of recombinant protein production.

Brown AJ, Gibson SJ, Hatton D, Arnall CL, James DC. Brown AJ, et al. Biotechnol Bioeng. 2019 Feb;116(2):375-387. doi: 10.1002/bit.26855. Epub 2018 Nov 5. Biotechnol Bioeng. 2019. PMID: 30345502 Free article.

2

Block decoys: transcription-factor decoys designed for in vitro gene regulation studies.

Brown AJ, Mainwaring DO, Sweeney B, James DC. Brown AJ, et al. Anal Biochem. 2013 Dec 15;443(2):205-10. doi: 10.1016/j.ab.2013.09.003. Epub 2013 Sep 10. Anal Biochem. 2013. PMID: 24036039

3

Synthetic promoters for CHO cell engineering.

Brown AJ, Sweeney B, Mainwaring DO, James DC. Brown AJ, et al. Biotechnol Bioeng. 2014 Aug;111(8):1638-47. doi: 10.1002/bit.25227. Epub 2014 May 1. Biotechnol Bioeng. 2014. PMID: 24615264

4

NF-κB, CRE and YY1 elements are key functional regulators of CMV promoter-driven transient gene expression in CHO cells.

Brown AJ, Sweeney B, Mainwaring DO, James DC. Brown AJ, et al. Biotechnol J. 2015 Jul;10(7):1019-28. doi: 10.1002/biot.201400744. Epub 2015 Feb 23. Biotechnol J. 2015. PMID: 25612069

5

Precision control of recombinant gene transcription for CHO cell synthetic biology.

Brown AJ, James DC. Brown AJ, et al. Biotechnol Adv. 2016 Sep-Oct;34(5):492-503. doi: 10.1016/j.biotechadv.2015.12.012. Epub 2015 Dec 23. Biotechnol Adv. 2016. PMID: 26721629 Review.

6

Transcriptome-Based Identification of the Optimal Reference CHO Genes for Normalisation of qPCR Data.

Brown AJ, Gibson S, Hatton D, James DC. Brown AJ, et al. Biotechnol J. 2018 Jan;13(1). doi: 10.1002/biot.201700259. Epub 2017 Sep 29. Biotechnol J. 2018. PMID: 28731643 Free article.

7

Constructing Strong Cell Type-Specific Promoters Through Informed Design.

Brown AJ, James DC. Brown AJ, et al. Methods Mol Biol. 2017;1651:131-145. doi: 10.1007/978-1-4939-7223-4_10. Methods Mol Biol. 2017. PMID: 28801904

8

In silico design of context-responsive mammalian promoters with user-defined functionality.

Brown AJ, Gibson SJ, Hatton D, James DC. Brown AJ, et al. Nucleic Acids Res. 2017 Oct 13;45(18):10906-10919. doi: 10.1093/nar/gkx768. Nucleic Acids Res. 2017. PMID: 28977454 Free PMC article.

9

CHO genome mining for synthetic promoter design.

Johari YB, Brown AJ, Alves CS, Zhou Y, Wright CM, Estes SD, Kshirsagar R, James DC. Johari YB, et al. Among authors: brown aj. J Biotechnol. 2019 Mar 20;294:1-13. doi: 10.1016/j.jbiotec.2019.01.015. Epub 2019 Jan 28. J Biotechnol. 2019. PMID: 30703471 Free article.

10

A platform for context-specific genetic engineering of recombinant protein production by CHO cells.

Cartwright JF, Arnall CL, Patel YD, Barber NOW, Lovelady CS, Rosignoli G, Harris CL, Dunn S, Field RP, Dean G, Daramola O, Gibson SJ, Peden AA, Brown AJ, Hatton D, James DC. Cartwright JF, et al. Among authors: brown aj. J Biotechnol. 2020 Mar 20;312:11-22. doi: 10.1016/j.jbiotec.2020.02.012. Epub 2020 Feb 27. J Biotechnol. 2020. PMID: 32114154

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