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The architecture of EGFR's basal complexes reveals autoinhibition mechanisms in dimers and oligomers.
Zanetti-Domingues LC, Korovesis D, Needham SR, Tynan CJ, Sagawa S, Roberts SK, Kuzmanic A, Ortiz-Zapater E, Jain P, Roovers RC, Lajevardipour A, van Bergen En Henegouwen PMP, Santis G, Clayton AHA, Clarke DT, Gervasio FL, Shan Y, Shaw DE, Rolfe DJ, Parker PJ, Martin-Fernandez ML. Zanetti-Domingues LC, et al. Among authors: parker pj. Nat Commun. 2018 Oct 18;9(1):4325. doi: 10.1038/s41467-018-06632-0. Nat Commun. 2018. PMID: 30337523 Free PMC article.
Effect of phosphorylation on EGFR dimer stability probed by single-molecule dynamics and FRET/FLIM.
Coban O, Zanetti-Dominguez LC, Matthews DR, Rolfe DJ, Weitsman G, Barber PR, Barbeau J, Devauges V, Kampmeier F, Winn M, Vojnovic B, Parker PJ, Lidke KA, Lidke DS, Ameer-Beg SM, Martin-Fernandez ML, Ng T. Coban O, et al. Among authors: parker pj. Biophys J. 2015 Mar 10;108(5):1013-26. doi: 10.1016/j.bpj.2015.01.005. Biophys J. 2015. PMID: 25762314 Free PMC article.
EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.
Needham SR, Roberts SK, Arkhipov A, Mysore VP, Tynan CJ, Zanetti-Domingues LC, Kim ET, Losasso V, Korovesis D, Hirsch M, Rolfe DJ, Clarke DT, Winn MD, Lajevardipour A, Clayton AH, Pike LJ, Perani M, Parker PJ, Shan Y, Shaw DE, Martin-Fernandez ML. Needham SR, et al. Among authors: parker pj. Nat Commun. 2016 Oct 31;7:13307. doi: 10.1038/ncomms13307. Nat Commun. 2016. PMID: 27796308 Free PMC article.
Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface.
Claus J, Patel G, Autore F, Colomba A, Weitsman G, Soliman TN, Roberts S, Zanetti-Domingues LC, Hirsch M, Collu F, George R, Ortiz-Zapater E, Barber PR, Vojnovic B, Yarden Y, Martin-Fernandez ML, Cameron A, Fraternali F, Ng T, Parker PJ. Claus J, et al. Among authors: parker pj. Elife. 2018 May 1;7:e32271. doi: 10.7554/eLife.32271. Elife. 2018. PMID: 29712619 Free PMC article.
A small molecule inhibitor of HER3: a proof-of-concept study.
Colomba A, Fitzek M, George R, Weitsman G, Roberts S, Zanetti-Domingues L, Hirsch M, Rolfe DJ, Mehmood S, Madin A, Claus J, Kjaer S, Snijders AP, Ng T, Martin-Fernandez M, Smith DM, Parker PJ. Colomba A, et al. Among authors: parker pj. Biochem J. 2020 Sep 18;477(17):3329-3347. doi: 10.1042/BCJ20200496. Biochem J. 2020. PMID: 32815546 Free PMC article.
Cluster Analysis of Endogenous HER2 and HER3 Receptors in SKBR3 Cells.
Roberts SK, Hirsch M, McStea A, Zanetti-Domingues LC, Clarke DT, Claus J, Parker PJ, Wang L, Martin-Fernandez AML. Roberts SK, et al. Among authors: parker pj. Bio Protoc. 2018 Dec 5;8(23):e3096. doi: 10.21769/BioProtoc.3096. eCollection 2018 Dec 5. Bio Protoc. 2018. PMID: 34532543 Free PMC article.
397 results