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Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia.
Chowdhury A, Aich A, Jain G, Wozny K, Lüchtenborg C, Hartmann M, Bernhard O, Balleiniger M, Alfar EA, Zieseniss A, Toischer K, Guan K, Rizzoli SO, Brügger B, Fischer A, Katschinski DM, Rehling P, Dudek J. Chowdhury A, et al. Among authors: toischer k. Cell Rep. 2018 Oct 16;25(3):561-570.e6. doi: 10.1016/j.celrep.2018.09.057. Cell Rep. 2018. PMID: 30332638 Free PMC article.
Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome.
Dudek J, Cheng IF, Chowdhury A, Wozny K, Balleininger M, Reinhold R, Grunau S, Callegari S, Toischer K, Wanders RJ, Hasenfuß G, Brügger B, Guan K, Rehling P. Dudek J, et al. Among authors: toischer k. EMBO Mol Med. 2016 Feb 1;8(2):139-54. doi: 10.15252/emmm.201505644. EMBO Mol Med. 2016. PMID: 26697888 Free PMC article.
Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression.
Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, Richter C, Zeisberg EM, Kattner L, Didié M, Guan K, Schmitto JD, Lehnart SE, Luther S, Voigt N, Seidler T, Sossalla S, Hasenfuss G, Toischer K. Mohamed BA, et al. Among authors: toischer k. Sci Transl Med. 2018 Sep 12;10(458):eaan0724. doi: 10.1126/scitranslmed.aan0724. Sci Transl Med. 2018. PMID: 30209242
Changes in m6A RNA methylation contribute to heart failure progression by modulating translation.
Berulava T, Buchholz E, Elerdashvili V, Pena T, Islam MR, Lbik D, Mohamed BA, Renner A, von Lewinski D, Sacherer M, Bohnsack KE, Bohnsack MT, Jain G, Capece V, Cleve N, Burkhardt S, Hasenfuss G, Fischer A, Toischer K. Berulava T, et al. Among authors: toischer k. Eur J Heart Fail. 2020 Jan;22(1):54-66. doi: 10.1002/ejhf.1672. Epub 2019 Dec 17. Eur J Heart Fail. 2020. PMID: 31849158 Free article.
Epigenetic gene expression links heart failure to memory impairment.
Islam MR, Lbik D, Sakib MS, Maximilian Hofmann R, Berulava T, Jiménez Mausbach M, Cha J, Goldberg M, Vakhtang E, Schiffmann C, Zieseniss A, Katschinski DM, Sananbenesi F, Toischer K, Fischer A. Islam MR, et al. Among authors: toischer k. EMBO Mol Med. 2021 Mar 5;13(3):e11900. doi: 10.15252/emmm.201911900. Epub 2021 Jan 20. EMBO Mol Med. 2021. PMID: 33471428 Free PMC article.
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
Iyer LM, Nagarajan S, Woelfer M, Schoger E, Khadjeh S, Zafiriou MP, Kari V, Herting J, Pang ST, Weber T, Rathjens FS, Fischer TH, Toischer K, Hasenfuss G, Noack C, Johnsen SA, Zelarayán LC. Iyer LM, et al. Among authors: toischer k. Nucleic Acids Res. 2018 Apr 6;46(6):2850-2867. doi: 10.1093/nar/gky049. Nucleic Acids Res. 2018. PMID: 29394407 Free PMC article.
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