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CPP-Ts: a new intracellular calcium channel modulator and a promising tool for drug delivery in cancer cells.
Oliveira-Mendes BBR, Horta CCR, do Carmo AO, Biscoto GL, Sales-Medina DF, Leal HG, Brandão-Dias PFP, Miranda SEM, Aguiar CJ, Cardoso VN, de Barros ALB, Chávez-Olortégui C, Leite MF, Kalapothakis E. Oliveira-Mendes BBR, et al. Among authors: aguiar cj. Sci Rep. 2018 Oct 3;8(1):14739. doi: 10.1038/s41598-018-33133-3. Sci Rep. 2018. PMID: 30282983 Free PMC article.
GPR91: expanding the frontiers of Krebs cycle intermediates.
de Castro Fonseca M, Aguiar CJ, da Rocha Franco JA, Gingold RN, Leite MF. de Castro Fonseca M, et al. Among authors: aguiar cj. Cell Commun Signal. 2016 Jan 12;14:3. doi: 10.1186/s12964-016-0126-1. Cell Commun Signal. 2016. PMID: 26759054 Free PMC article. Review.
Nuclear Ca2+ regulates cardiomyocyte function.
Guatimosim S, Amaya MJ, Guerra MT, Aguiar CJ, Goes AM, Gómez-Viquez NL, Rodrigues MA, Gomes DA, Martins-Cruz J, Lederer WJ, Leite MF. Guatimosim S, et al. Among authors: aguiar cj. Cell Calcium. 2008 Aug;44(2):230-42. doi: 10.1016/j.ceca.2007.11.016. Epub 2008 Jan 16. Cell Calcium. 2008. PMID: 18201761
Mitochondrial calcium regulates rat liver regeneration through the modulation of apoptosis.
Guerra MT, Fonseca EA, Melo FM, Andrade VA, Aguiar CJ, Andrade LM, Pinheiro AC, Casteluber MC, Resende RR, Pinto MC, Fernandes SO, Cardoso VN, Souza-Fagundes EM, Menezes GB, de Paula AM, Nathanson MH, Leite Mde F. Guerra MT, et al. Among authors: aguiar cj. Hepatology. 2011 Jul;54(1):296-306. doi: 10.1002/hep.24367. Hepatology. 2011. PMID: 21503946 Free PMC article.
Nuclear inositol 1,4,5-trisphosphate is a necessary and conserved signal for the induction of both pathological and physiological cardiomyocyte hypertrophy.
Arantes LA, Aguiar CJ, Amaya MJ, Figueiró NC, Andrade LM, Rocha-Resende C, Resende RR, Franchini KG, Guatimosim S, Leite MF. Arantes LA, et al. Among authors: aguiar cj. J Mol Cell Cardiol. 2012 Oct;53(4):475-86. doi: 10.1016/j.yjmcc.2012.06.017. Epub 2012 Jul 2. J Mol Cell Cardiol. 2012. PMID: 22766271
Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation.
Aguiar CJ, Rocha-Franco JA, Sousa PA, Santos AK, Ladeira M, Rocha-Resende C, Ladeira LO, Resende RR, Botoni FA, Barrouin Melo M, Lima CX, Carballido JM, Cunha TM, Menezes GB, Guatimosim S, Leite MF. Aguiar CJ, et al. Cell Commun Signal. 2014 Dec 24;12:78. doi: 10.1186/s12964-014-0078-2. Cell Commun Signal. 2014. PMID: 25539979 Free PMC article.