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Transcriptional repressor REST drives lineage stage-specific chromatin compaction at Ptch1 and increases AKT activation in a mouse model of medulloblastoma.
Dobson THW, Tao RH, Swaminathan J, Maegawa S, Shaik S, Bravo-Alegria J, Sharma A, Kennis B, Yang Y, Callegari K, Haltom AR, Taylor P, Kogiso M, Qi L, Khatua S, Goldman S, Lulla RR, Fangusaro J, MacDonald TJ, Li XN, Hawkins C, Rajaram V, Gopalakrishnan V. Dobson THW, et al. Sci Signal. 2019 Jan 22;12(565):eaan8680. doi: 10.1126/scisignal.aan8680. Sci Signal. 2019. PMID: 30670636 Free PMC article.
REST promotes ETS1-dependent vascular growth in medulloblastoma.
Shaik S, Maegawa S, Haltom AR, Wang F, Xiao X, Dobson T, Sharma A, Yang Y, Swaminathan J, Kundra V, Li XN, Schadler K, Harmanci A, Xu L, Gopalakrishnan V. Shaik S, et al. Mol Oncol. 2021 May;15(5):1486-1506. doi: 10.1002/1878-0261.12903. Epub 2021 Feb 7. Mol Oncol. 2021. PMID: 33469989 Free PMC article.
Splicing is an alternate oncogenic pathway activation mechanism in glioma.
Siddaway R, Milos S, Vadivel AKA, Dobson THW, Swaminathan J, Ryall S, Pajovic S, Patel PG, Nazarian J, Becher O, Brudno M, Ramani A, Gopalakrishnan V, Hawkins C. Siddaway R, et al. Among authors: dobson thw. Nat Commun. 2022 Jan 31;13(1):588. doi: 10.1038/s41467-022-28253-4. Nat Commun. 2022. PMID: 35102191 Free PMC article.