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Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx.
Crompton M, Ferguson JK, Ramnath RD, Onions KL, Ogier AS, Gamez M, Down CJ, Skinner L, Wong KH, Dixon LK, Sutak J, Harper SJ, Pontrelli P, Gesualdo L, Heerspink HL, Toto RD, Welsh GI, Foster RR, Satchell SC, Butler MJ. Crompton M, et al. Among authors: satchell sc. JCI Insight. 2023 Mar 8;8(5):e154164. doi: 10.1172/jci.insight.154164. JCI Insight. 2023. PMID: 36749631 Free PMC article. Clinical Trial.
Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice.
Qiu Y, Buffonge S, Ramnath R, Jenner S, Fawaz S, Arkill KP, Neal C, Verkade P, White SJ, Hezzell M, Salmon AHJ, Suleiman MS, Welsh GI, Foster RR, Madeddu P, Satchell SC. Qiu Y, et al. Among authors: satchell sc. Diabetologia. 2022 May;65(5):879-894. doi: 10.1007/s00125-022-05650-4. Epub 2022 Feb 25. Diabetologia. 2022. PMID: 35211778 Free PMC article.
A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli.
Desideri S, Onions KL, Qiu Y, Ramnath RD, Butler MJ, Neal CR, King MLR, Salmon AE, Saleem MA, Welsh GI, Michel CC, Satchell SC, Salmon AHJ, Foster RR. Desideri S, et al. Among authors: satchell sc. Kidney Int. 2018 May;93(5):1086-1097. doi: 10.1016/j.kint.2017.12.003. Epub 2018 Feb 9. Kidney Int. 2018. PMID: 29433915 Free PMC article.
122 results