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In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate.
Fuller JC Jr, Pitchford LM, Morrison RD, Daniels JS, Flynn CR, Abumrad NN, Oates JA, Boutaud O, Rathmacher JA. Fuller JC Jr, et al. Among authors: morrison rd. Food Chem Toxicol. 2018 Nov;121:541-548. doi: 10.1016/j.fct.2018.09.047. Epub 2018 Sep 22. Food Chem Toxicol. 2018. PMID: 30253245 Free PMC article.
First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers.
Pitchford LM, Rathmacher JA, Fuller JC Jr, Daniels JS, Morrison RD, Akers WS, Abumrad NN, Amarnath V, Currey PM, Roberts LJ, Oates JA, Boutaud O. Pitchford LM, et al. Among authors: morrison rd. BMC Pharmacol Toxicol. 2019 Jan 5;20(1):1. doi: 10.1186/s40360-018-0281-7. BMC Pharmacol Toxicol. 2019. PMID: 30611293 Free PMC article. Clinical Trial.
Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1.
Manka JT, Rodriguez AL, Morrison RD, Venable DF, Cho HP, Blobaum AL, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA. Manka JT, et al. Among authors: morrison rd. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5091-6. doi: 10.1016/j.bmcl.2013.07.029. Epub 2013 Jul 23. Bioorg Med Chem Lett. 2013. PMID: 23932792 Free PMC article.
Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism.
Bridges TM, Rook JM, Noetzel MJ, Morrison RD, Zhou Y, Gogliotti RD, Vinson PN, Xiang Z, Jones CK, Niswender CM, Lindsley CW, Stauffer SR, Conn PJ, Daniels JS. Bridges TM, et al. Among authors: morrison rd. Drug Metab Dispos. 2013 Sep;41(9):1703-14. doi: 10.1124/dmd.113.052084. Epub 2013 Jul 2. Drug Metab Dispos. 2013. PMID: 23821185 Free PMC article.
Medication Exposure in Highly Adherent Psychiatry Patients.
Sutherland JJ, Daly TM, Jacobs K, Khawam EA, Pozuelo L, Morrison RD, Milne SB, Daniels JS, Ryan TP. Sutherland JJ, et al. Among authors: morrison rd. ACS Chem Neurosci. 2018 Mar 21;9(3):555-562. doi: 10.1021/acschemneuro.7b00375. Epub 2017 Dec 1. ACS Chem Neurosci. 2018. PMID: 29155555
Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.
Lavieri RR, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD, Daniels JS, Brown HA, Lindsley CW. Lavieri RR, et al. Among authors: morrison rd. J Med Chem. 2010 Sep 23;53(18):6706-19. doi: 10.1021/jm100814g. J Med Chem. 2010. PMID: 20735042 Free PMC article.
109 results