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Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones.
Nat Commun. 2018 Sep 21;9(1):3860. doi: 10.1038/s41467-018-06192-3.
Nat Commun. 2018.
PMID: 30242155
Free PMC article.
Full-length human GLP-1 receptor structure without orthosteric ligands.
Wu F, Yang L, Hang K, Laursen M, Wu L, Han GW, Ren Q, Roed NK, Lin G, Hanson MA, Jiang H, Wang MW, Reedtz-Runge S, Song G, Stevens RC.
Wu F, et al. Among authors: roed nk.
Nat Commun. 2020 Mar 9;11(1):1272. doi: 10.1038/s41467-020-14934-5.
Nat Commun. 2020.
PMID: 32152292
Free PMC article.
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NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor.
Rasmussen KK, Falkesgaard MH, Winther M, Roed NK, Quistgaard CL, Teisen MN, Edslev SM, Petersen DL, Aljubouri A, Christensen C, Thulstrup PW, Lo Leggio L, Teilum K, Walmod PS.
Rasmussen KK, et al. Among authors: roed nk.
Sci Rep. 2018 Jun 12;8(1):8957. doi: 10.1038/s41598-018-27089-7.
Sci Rep. 2018.
PMID: 29895898
Free PMC article.
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Dual treatment with a fixed ratio of glucagon and insulin increases the therapeutic window of insulin in diabetic rats.
Pedersen C, Bouman SD, Porsgaard T, Rosenkilde MM, Roed NK.
Pedersen C, et al. Among authors: roed nk.
Physiol Rep. 2018 Mar;6(6):e13657. doi: 10.14814/phy2.13657.
Physiol Rep. 2018.
PMID: 29595915
Free PMC article.
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Sustained effect of glucagon on body weight and blood glucose: Assessed by continuous glucose monitoring in diabetic rats.
Pedersen C, Porsgaard T, Thomsen M, Rosenkilde MM, Roed NK.
Pedersen C, et al. Among authors: roed nk.
PLoS One. 2018 Mar 20;13(3):e0194468. doi: 10.1371/journal.pone.0194468. eCollection 2018.
PLoS One. 2018.
PMID: 29558502
Free PMC article.
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Preclinical exploration of combined glucagon inhibition and liver-preferential insulin for treatment of diabetes using in vitro assays and rat and mouse models.
Hvid H, Brand CL, Hummelshøj T, Jensen S, Bouman SD, Bowler A, Poulsen BR, Tiainen P, Åkertröm T, Demozay D, Hoeg-Jensen T, Ingvorsen C, Pedersen TÅ, McGuire J, Egebjerg T, Cappelen KA, Eliasen IP, Hansen BF, Hennen S, Stidsen CE, Olsen GS, Roed NK.
Hvid H, et al. Among authors: roed nk.
Diabetologia. 2023 Feb;66(2):376-389. doi: 10.1007/s00125-022-05828-w. Epub 2022 Nov 21.
Diabetologia. 2023.
PMID: 36404376
Free PMC article.
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