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Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones.
Roed NK, Viola CM, Kristensen O, Schluckebier G, Norrman M, Sajid W, Wade JD, Andersen AS, Kristensen C, Ganderton TR, Turkenburg JP, De Meyts P, Brzozowski AM. Roed NK, et al. Among authors: kristensen o, kristensen c. Nat Commun. 2018 Sep 21;9(1):3860. doi: 10.1038/s41467-018-06192-3. Nat Commun. 2018. PMID: 30242155 Free PMC article.
Dimeric fragment of the insulin receptor alpha-subunit binds insulin with full holoreceptor affinity.
Brandt J, Andersen AS, Kristensen C. Brandt J, et al. Among authors: kristensen c. J Biol Chem. 2001 Apr 13;276(15):12378-84. doi: 10.1074/jbc.M009402200. Epub 2001 Jan 12. J Biol Chem. 2001. PMID: 11278498 Free article.
We have previously shown that a minimized insulin receptor consisting of the first three domains of the human IR fused to 16 amino acids from the C-terminal of the alpha-subunit was monomeric and bound insulin with nanomolar affinity (Kristensen, C., Wiberg, …
We have previously shown that a minimized insulin receptor consisting of the first three domains of the human IR fused to 16 amino acids fro …
Functional reconstitution of insulin receptor binding site from non-binding receptor fragments.
Kristensen C, Andersen AS, Ostergaard S, Hansen PH, Brandt J. Kristensen C, et al. J Biol Chem. 2002 May 24;277(21):18340-5. doi: 10.1074/jbc.M112249200. Epub 2002 Mar 18. J Biol Chem. 2002. PMID: 11901156 Free article.
We have previously shown that a minimized insulin receptor (IR) consisting of the first 468 amino acids of the insulin receptor fused to 16 amino acids from the C terminus of the alpha-subunit (CT domain) bound insulin with nanomolar affinity (Kristensen, C., …
We have previously shown that a minimized insulin receptor (IR) consisting of the first 468 amino acids of the insulin receptor fused to 16 …
Alanine scanning mutagenesis of insulin.
Kristensen C, Kjeldsen T, Wiberg FC, Schäffer L, Hach M, Havelund S, Bass J, Steiner DF, Andersen AS. Kristensen C, et al. J Biol Chem. 1997 May 16;272(20):12978-83. doi: 10.1074/jbc.272.20.12978. J Biol Chem. 1997. PMID: 9148904 Free article.
The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells.
Tian W, Ye Z, Wang S, Schulz MA, Van Coillie J, Sun L, Chen YH, Narimatsu Y, Hansen L, Kristensen C, Mandel U, Bennett EP, Jabbarzadeh-Tabrizi S, Schiffmann R, Shen JS, Vakhrushev SY, Clausen H, Yang Z. Tian W, et al. Among authors: kristensen c. Nat Commun. 2019 Apr 30;10(1):1785. doi: 10.1038/s41467-019-09809-3. Nat Commun. 2019. PMID: 31040271 Free PMC article.
304 results