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Insulin regulates POMC neuronal plasticity to control glucose metabolism.
Dodd GT, Michael NJ, Lee-Young RS, Mangiafico SP, Pryor JT, Munder AC, Simonds SE, Brüning JC, Zhang ZY, Cowley MA, Andrikopoulos S, Horvath TL, Spanswick D, Tiganis T. Dodd GT, et al. Among authors: zhang zy. Elife. 2018 Sep 19;7:e38704. doi: 10.7554/eLife.38704. Elife. 2018. PMID: 30230471 Free PMC article.
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.
Loh K, Fukushima A, Zhang X, Galic S, Briggs D, Enriori PJ, Simonds S, Wiede F, Reichenbach A, Hauser C, Sims NA, Bence KK, Zhang S, Zhang ZY, Kahn BB, Neel BG, Andrews ZB, Cowley MA, Tiganis T. Loh K, et al. Among authors: zhang s, zhang zy, zhang x. Cell Metab. 2011 Nov 2;14(5):684-99. doi: 10.1016/j.cmet.2011.09.011. Epub 2011 Oct 13. Cell Metab. 2011. PMID: 22000926 Free PMC article.
Leptin and insulin act on POMC neurons to promote the browning of white fat.
Dodd GT, Decherf S, Loh K, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg H, Zhang ZY, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, Tiganis T. Dodd GT, et al. Among authors: zhang zy. Cell. 2015 Jan 15;160(1-2):88-104. doi: 10.1016/j.cell.2014.12.022. Cell. 2015. PMID: 25594176 Free PMC article.
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.
Wiede F, Lu KH, Du X, Liang S, Hochheiser K, Dodd GT, Goh PK, Kearney C, Meyran D, Beavis PA, Henderson MA, Park SL, Waithman J, Zhang S, Zhang ZY, Oliaro J, Gebhardt T, Darcy PK, Tiganis T. Wiede F, et al. Among authors: zhang s, zhang zy. EMBO J. 2020 Jan 15;39(2):e103637. doi: 10.15252/embj.2019103637. Epub 2019 Dec 5. EMBO J. 2020. PMID: 31803974 Free PMC article.
Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy.
Dong J, Miao J, Miao Y, Qu Z, Zhang S, Zhu P, Wiede F, Jassim BA, Bai Y, Nguyen Q, Lin J, Chen L, Tiganis T, Tao WA, Zhang ZY. Dong J, et al. Among authors: zhang s, zhang zy. Angew Chem Int Ed Engl. 2023 May 22;62(22):e202303818. doi: 10.1002/anie.202303818. Epub 2023 Apr 21. Angew Chem Int Ed Engl. 2023. PMID: 36973833 Free PMC article.
A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity.
Liang S, Tran E, Du X, Dong J, Sudholz H, Chen H, Qu Z, Huntington ND, Babon JJ, Kershaw NJ, Zhang ZY, Baell JB, Wiede F, Tiganis T. Liang S, et al. Among authors: zhang zy. Nat Commun. 2023 Jul 27;14(1):4524. doi: 10.1038/s41467-023-40170-8. Nat Commun. 2023. PMID: 37500611 Free PMC article.
3,450 results