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A high throughput screen for next-generation leads targeting malaria parasite transmission.
Delves MJ, Miguel-Blanco C, Matthews H, Molina I, Ruecker A, Yahiya S, Straschil U, Abraham M, León ML, Fischer OJ, Rueda-Zubiaurre A, Brandt JR, Cortés Á, Barnard A, Fuchter MJ, Calderón F, Winzeler EA, Sinden RE, Herreros E, Gamo FJ, Baum J. Delves MJ, et al. Among authors: fuchter mj. Nat Commun. 2018 Sep 18;9(1):3805. doi: 10.1038/s41467-018-05777-2. Nat Commun. 2018. PMID: 30228275 Free PMC article.
Data-driven discovery of molecular photoswitches with multioutput Gaussian processes.
Griffiths RR, Greenfield JL, Thawani AR, Jamasb AR, Moss HB, Bourached A, Jones P, McCorkindale W, Aldrick AA, Fuchter MJ, Lee AA. Griffiths RR, et al. Among authors: fuchter mj. Chem Sci. 2022 Nov 10;13(45):13541-13551. doi: 10.1039/d2sc04306h. eCollection 2022 Nov 23. Chem Sci. 2022. PMID: 36507171 Free PMC article.
Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans.
Malmquist NA, Sundriyal S, Caron J, Chen P, Witkowski B, Menard D, Suwanarusk R, Renia L, Nosten F, Jiménez-Díaz MB, Angulo-Barturen I, Santos Martínez M, Ferrer S, Sanz LM, Gamo FJ, Wittlin S, Duffy S, Avery VM, Ruecker A, Delves MJ, Sinden RE, Fuchter MJ, Scherf A. Malmquist NA, et al. Among authors: fuchter mj. Antimicrob Agents Chemother. 2015 Feb;59(2):950-9. doi: 10.1128/AAC.04419-14. Epub 2014 Nov 24. Antimicrob Agents Chemother. 2015. PMID: 25421480 Free PMC article.
Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum.
Lubin AS, Rueda-Zubiaurre A, Matthews H, Baumann H, Fisher FR, Morales-Sanfrutos J, Hadavizadeh KS, Nardella F, Tate EW, Baum J, Scherf A, Fuchter MJ. Lubin AS, et al. Among authors: fuchter mj. ACS Infect Dis. 2018 Apr 13;4(4):523-530. doi: 10.1021/acsinfecdis.7b00228. Epub 2018 Feb 5. ACS Infect Dis. 2018. PMID: 29377668 Free PMC article.
121 results