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Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor.
Stahl S, da Silva Mateus Seidl AR, Ducret A, Kux van Geijtenbeek S, Michel S, Racek T, Birzele F, Haas AK, Rueger R, Gerg M, Niederfellner G, Pastan I, Brinkmann U. Stahl S, et al. Among authors: birzele f. Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10732-7. doi: 10.1073/pnas.1512863112. Epub 2015 Aug 10. Proc Natl Acad Sci U S A. 2015. PMID: 26261303 Free PMC article.
A re-engineered immunotoxin shows promising preclinical activity in ovarian cancer.
Kollmorgen G, Palme K, Seidl A, Scheiblich S, Birzele F, Wilson S, Clemens C, Voss E, Kaufmann M, Hirzel K, Rieder N, Krippendorff BF, Herting F, Niederfellner G. Kollmorgen G, et al. Among authors: birzele f. Sci Rep. 2017 Dec 22;7(1):18086. doi: 10.1038/s41598-017-17329-7. Sci Rep. 2017. PMID: 29273809 Free PMC article.
59 results