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The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice.
Kindt A, Liebisch G, Clavel T, Haller D, Hörmannsperger G, Yoon H, Kolmeder D, Sigruener A, Krautbauer S, Seeliger C, Ganzha A, Schweizer S, Morisset R, Strowig T, Daniel H, Helm D, Küster B, Krumsiek J, Ecker J. Kindt A, et al. Among authors: ganzha a. Nat Commun. 2018 Sep 14;9(1):3760. doi: 10.1038/s41467-018-05767-4. Nat Commun. 2018. PMID: 30218046 Free PMC article.
Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling.
Otto AC, Gan-Schreier H, Zhu X, Tuma-Kellner S, Staffer S, Ganzha A, Liebisch G, Chamulitrat W. Otto AC, et al. Among authors: ganzha a. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):662-676. doi: 10.1016/j.bbalip.2019.01.012. Epub 2019 Feb 5. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 30735855
iPla2β deficiency in mice fed with MCD diet does not correct the defect of phospholipid remodeling but attenuates hepatocellular injury via an inhibition of lipid uptake genes.
Zhu X, Gan-Schreier H, Otto AC, Cheng Y, Staffer S, Tuma-Kellner S, Ganzha A, Liebisch G, Chamulitrat W. Zhu X, et al. Among authors: ganzha a. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):677-687. doi: 10.1016/j.bbalip.2019.02.003. Epub 2019 Feb 5. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 30735854