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The saturation degree of fatty acids and their derived acylcarnitines determines the direct effect of metabolically active thyroid hormones on insulin sensitivity in skeletal muscle cells.
Giacco A, Delli Paoli G, Senese R, Cioffi F, Silvestri E, Moreno M, Ruoppolo M, Caterino M, Costanzo M, Lombardi A, Goglia F, Lanni A, de Lange P. Giacco A, et al. Among authors: senese r. FASEB J. 2019 Feb;33(2):1811-1823. doi: 10.1096/fj.201800724R. Epub 2018 Sep 11. FASEB J. 2019. PMID: 30204501
The results show that T2 and T3 both invert the fatty acid-induced response to insulin but through different mechanisms, and that the outcome depends on the degree of saturation of the fatty acids and their derived acylcarnitines.-Giacco, A., delli Paoli, G., Senese, R …
The results show that T2 and T3 both invert the fatty acid-induced response to insulin but through different mechanisms, and that the outcom …
Rapid activation by 3,5,3'-L-triiodothyronine of adenosine 5'-monophosphate-activated protein kinase/acetyl-coenzyme a carboxylase and akt/protein kinase B signaling pathways: relation to changes in fuel metabolism and myosin heavy-chain protein content in rat gastrocnemius muscle in vivo.
de Lange P, Senese R, Cioffi F, Moreno M, Lombardi A, Silvestri E, Goglia F, Lanni A. de Lange P, et al. Among authors: senese r. Endocrinology. 2008 Dec;149(12):6462-70. doi: 10.1210/en.2008-0202. Epub 2008 Aug 14. Endocrinology. 2008. PMID: 18703632
TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet.
Cioffi F, Zambad SP, Chhipa L, Senese R, Busiello RA, Tuli D, Munshi S, Moreno M, Lombardi A, Gupta RC, Chauthaiwale V, Dutt C, de Lange P, Silvestri E, Lanni A, Goglia F. Cioffi F, et al. Among authors: senese r. FASEB J. 2010 Sep;24(9):3451-61. doi: 10.1096/fj.10-157115. Epub 2010 May 7. FASEB J. 2010. PMID: 20453112
62 results