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Phosphoinositide 3-kinase p110α is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction.
Weeks KL, Gao X, Du XJ, Boey EJ, Matsumoto A, Bernardo BC, Kiriazis H, Cemerlang N, Tan JW, Tham YK, Franke TF, Qian H, Bogoyevitch MA, Woodcock EA, Febbraio MA, Gregorevic P, McMullen JR. Weeks KL, et al. Circ Heart Fail. 2012 Jul 1;5(4):523-34. doi: 10.1161/CIRCHEARTFAILURE.112.966622. Epub 2012 Jun 15. Circ Heart Fail. 2012. PMID: 22705768
Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling.
Bernardo BC, Weeks KL, Pongsukwechkul T, Gao X, Kiriazis H, Cemerlang N, Boey EJH, Tham YK, Johnson CJ, Qian H, Du XJ, Gregorevic P, McMullen JR. Bernardo BC, et al. Among authors: weeks kl. Clin Sci (Lond). 2018 Feb 8;132(3):381-397. doi: 10.1042/CS20171269. Print 2018 Feb 14. Clin Sci (Lond). 2018. PMID: 29358507
FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K.
Weeks KL, Tham YK, Yildiz SG, Alexander Y, Donner DG, Kiriazis H, Harmawan CA, Hsu A, Bernardo BC, Matsumoto A, DePinho RA, Abel ED, Woodcock EA, McMullen JR. Weeks KL, et al. Am J Physiol Heart Circ Physiol. 2021 Apr 1;320(4):H1470-H1485. doi: 10.1152/ajpheart.00838.2020. Epub 2021 Feb 12. Am J Physiol Heart Circ Physiol. 2021. PMID: 33577435 Free article.
44 results