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PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation.
Petrelli A, Mijnheer G, Hoytema van Konijnenburg DP, van der Wal MM, Giovannone B, Mocholi E, Vazirpanah N, Broen JC, Hijnen D, Oldenburg B, Coffer PJ, Vastert SJ, Prakken BJ, Spierings E, Pandit A, Mokry M, van Wijk F. Petrelli A, et al. Among authors: broen jc. J Clin Invest. 2018 Oct 1;128(10):4669-4681. doi: 10.1172/JCI96107. Epub 2018 Aug 2. J Clin Invest. 2018. PMID: 30198907 Free PMC article. Clinical Trial.
Neonatal thymectomy reveals differentiation and plasticity within human naive T cells.
van den Broek T, Delemarre EM, Janssen WJ, Nievelstein RA, Broen JC, Tesselaar K, Borghans JA, Nieuwenhuis EE, Prakken BJ, Mokry M, Jansen NJ, van Wijk F. van den Broek T, et al. Among authors: broen jc. J Clin Invest. 2016 Mar 1;126(3):1126-36. doi: 10.1172/JCI84997. Epub 2016 Feb 22. J Clin Invest. 2016. PMID: 26901814 Free PMC article.
Patients with gout have short telomeres compared with healthy participants: association of telomere length with flare frequency and cardiovascular disease in gout.
Vazirpanah N, Kienhorst LBE, Van Lochem E, Wichers C, Rossato M, Shiels PG, Dalbeth N, Stamp LK, Merriman TR, Janssen M, Radstake TRDJ, Broen JC. Vazirpanah N, et al. Among authors: broen jc. Ann Rheum Dis. 2017 Jul;76(7):1313-1319. doi: 10.1136/annrheumdis-2016-210538. Epub 2017 Mar 27. Ann Rheum Dis. 2017. PMID: 28347991 Free article.
Aberrant leukocyte telomere length in Birdshot Uveitis.
Vazirpanah N, Verhagen FH, Rothova A, Missotten TOAR, van Velthoven M, Den Hollander AI, Hoyng CB, Radstake TRDJ, Broen JCA, Kuiper JJW. Vazirpanah N, et al. PLoS One. 2017 May 1;12(5):e0176175. doi: 10.1371/journal.pone.0176175. eCollection 2017. PLoS One. 2017. PMID: 28459868 Free PMC article.
mTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: a prelude to a new add-on therapy?
Vazirpanah N, Ottria A, van der Linden M, Wichers CGK, Schuiveling M, van Lochem E, Phipps-Green A, Merriman T, Zimmermann M, Jansen M, Radstake TRDJ, Broen JCA. Vazirpanah N, et al. Among authors: broen jca. Ann Rheum Dis. 2019 May;78(5):663-671. doi: 10.1136/annrheumdis-2018-214656. Epub 2019 Feb 27. Ann Rheum Dis. 2019. PMID: 30814053
Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis.
Affandi AJ, Carvalheiro T, Ottria A, Broen JC, Bossini-Castillo L, Tieland RG, Bon LV, Chouri E, Rossato M, Mertens JS, Garcia S, Pandit A, de Kroon LM, Christmann RB, Martin J, van Roon JA, Radstake TR, Marut W. Affandi AJ, et al. Among authors: broen jc. Ann Rheum Dis. 2019 Sep;78(9):1249-1259. doi: 10.1136/annrheumdis-2018-214991. Epub 2019 May 24. Ann Rheum Dis. 2019. PMID: 31126957
62 results