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Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity.
Saher O, Rocha CSJ, Zaghloul EM, Wiklander OPB, Zamolo S, Heitz M, Ezzat K, Gupta D, Reymond JL, Zain R, Hollfelder F, Darbre T, Lundin KE, El Andaloussi S, Smith CIE. Saher O, et al. Among authors: ezzat k. Eur J Pharm Biopharm. 2018 Nov;132:29-40. doi: 10.1016/j.ejpb.2018.09.002. Epub 2018 Sep 4. Eur J Pharm Biopharm. 2018. PMID: 30193928
Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo.
Bazaz S, Lehto T, Tops R, Gissberg O, Gupta D, Bestas B, Bost J, Wiklander OPB, Sork H, Zaghloul EM, Mamand DR, Hällbrink M, Sillard R, Saher O, Ezzat K, Smith CIE, Andaloussi SE, Lehto T. Bazaz S, et al. Among authors: ezzat k. Biomedicines. 2021 Aug 19;9(8):1046. doi: 10.3390/biomedicines9081046. Biomedicines. 2021. PMID: 34440250 Free PMC article.
PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation.
Ezzat K, Andaloussi SE, Zaghloul EM, Lehto T, Lindberg S, Moreno PM, Viola JR, Magdy T, Abdo R, Guterstam P, Sillard R, Hammond SM, Wood MJ, Arzumanov AA, Gait MJ, Smith CI, Hällbrink M, Langel Ü. Ezzat K, et al. Nucleic Acids Res. 2011 Jul;39(12):5284-98. doi: 10.1093/nar/gkr072. Epub 2011 Feb 23. Nucleic Acids Res. 2011. PMID: 21345932 Free PMC article.
Peptides for nucleic acid delivery.
Lehto T, Ezzat K, Wood MJA, El Andaloussi S. Lehto T, et al. Among authors: ezzat k. Adv Drug Deliv Rev. 2016 Nov 15;106(Pt A):172-182. doi: 10.1016/j.addr.2016.06.008. Epub 2016 Jun 25. Adv Drug Deliv Rev. 2016. PMID: 27349594 Free article. Review.
Peptide-based matrices as drug delivery vehicles.
Ezzat K, El Andaloussi S, Abdo R, Langel U. Ezzat K, et al. Curr Pharm Des. 2010;16(9):1167-78. doi: 10.2174/138161210790963832. Curr Pharm Des. 2010. PMID: 20030616 Review.
Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo.
Andaloussi SE, Lehto T, Mäger I, Rosenthal-Aizman K, Oprea II, Simonson OE, Sork H, Ezzat K, Copolovici DM, Kurrikoff K, Viola JR, Zaghloul EM, Sillard R, Johansson HJ, Said Hassane F, Guterstam P, Suhorutšenko J, Moreno PM, Oskolkov N, Hälldin J, Tedebark U, Metspalu A, Lebleu B, Lehtiö J, Smith CI, Langel U. Andaloussi SE, et al. Among authors: ezzat k. Nucleic Acids Res. 2011 May;39(9):3972-87. doi: 10.1093/nar/gkq1299. Epub 2011 Jan 17. Nucleic Acids Res. 2011. PMID: 21245043 Free PMC article.
A peptide-based vector for efficient gene transfer in vitro and in vivo.
Lehto T, Simonson OE, Mäger I, Ezzat K, Sork H, Copolovici DM, Viola JR, Zaghloul EM, Lundin P, Moreno PM, Mäe M, Oskolkov N, Suhorutšenko J, Smith CI, Andaloussi SE. Lehto T, et al. Among authors: ezzat k. Mol Ther. 2011 Aug;19(8):1457-67. doi: 10.1038/mt.2011.10. Epub 2011 Feb 22. Mol Ther. 2011. PMID: 21343913 Free PMC article.
Synthetic SiRNA Delivery: Progress and Prospects.
Roberts TC, Ezzat K, El Andaloussi S, Weinberg MS. Roberts TC, et al. Among authors: ezzat k. Methods Mol Biol. 2016;1364:291-310. doi: 10.1007/978-1-4939-3112-5_23. Methods Mol Biol. 2016. PMID: 26472459 Review.
Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides.
Ezzat K, Aoki Y, Koo T, McClorey G, Benner L, Coenen-Stass A, O'Donovan L, Lehto T, Garcia-Guerra A, Nordin J, Saleh AF, Behlke M, Morris J, Goyenvalle A, Dugovic B, Leumann C, Gordon S, Gait MJ, El-Andaloussi S, Wood MJ. Ezzat K, et al. Nano Lett. 2015 Jul 8;15(7):4364-73. doi: 10.1021/acs.nanolett.5b00490. Epub 2015 Jun 15. Nano Lett. 2015. PMID: 26042553 Free PMC article.
44 results