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Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.
King AJ, Siegel M, He Y, Nie B, Wang J, Koo-McCoy S, Minassian NA, Jafri Q, Pan D, Kohler J, Kumaraswamy P, Kozuka K, Lewis JG, Dragoli D, Rosenbaum DP, O'Neill D, Plain A, Greasley PJ, Jönsson-Rylander AC, Karlsson D, Behrendt M, Strömstedt M, Ryden-Bergsten T, Knöpfel T, Pastor Arroyo EM, Hernando N, Marks J, Donowitz M, Wagner CA, Alexander RT, Caldwell JS. King AJ, et al. Among authors: knopfel t. Sci Transl Med. 2018 Aug 29;10(456):eaam6474. doi: 10.1126/scitranslmed.aam6474. Sci Transl Med. 2018. PMID: 30158152 Free PMC article. Clinical Trial.
Paracellular transport of phosphate along the intestine.
Knöpfel T, Himmerkus N, Günzel D, Bleich M, Hernando N, Wagner CA. Knöpfel T, et al. Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2):G233-G241. doi: 10.1152/ajpgi.00032.2019. Epub 2019 Jun 6. Am J Physiol Gastrointest Liver Physiol. 2019. PMID: 31169994 Free article.
The proton-activated ovarian cancer G protein-coupled receptor 1 (OGR1) is responsible for renal calcium loss during acidosis.
Imenez Silva PH, Katamesh-Benabbas C, Chan K, Pastor Arroyo EM, Knöpfel T, Bettoni C, Ludwig MG, Gasser JA, Brandao-Burch A, Arnett TR, Bonny O, Seuwen K, Wagner CA. Imenez Silva PH, et al. Among authors: knopfel t. Kidney Int. 2020 May;97(5):920-933. doi: 10.1016/j.kint.2019.12.006. Epub 2019 Dec 25. Kidney Int. 2020. PMID: 32173037 Free article.
243 results