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Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.
King AJ, Siegel M, He Y, Nie B, Wang J, Koo-McCoy S, Minassian NA, Jafri Q, Pan D, Kohler J, Kumaraswamy P, Kozuka K, Lewis JG, Dragoli D, Rosenbaum DP, O'Neill D, Plain A, Greasley PJ, Jönsson-Rylander AC, Karlsson D, Behrendt M, Strömstedt M, Ryden-Bergsten T, Knöpfel T, Pastor Arroyo EM, Hernando N, Marks J, Donowitz M, Wagner CA, Alexander RT, Caldwell JS. King AJ, et al. Sci Transl Med. 2018 Aug 29;10(456):eaam6474. doi: 10.1126/scitranslmed.aam6474. Sci Transl Med. 2018. PMID: 30158152 Free PMC article. Clinical Trial.
Evaluation of the Pharmacodynamic Effects of the Potassium Binder RDX7675 in Mice.
Davidson JP, King AJ, Kumaraswamy P, Caldwell JS, Korner P, Blanks RC, Jacobs JW. Davidson JP, et al. Among authors: king aj. J Cardiovasc Pharmacol Ther. 2018 May;23(3):244-253. doi: 10.1177/1074248417741685. Epub 2017 Nov 12. J Cardiovasc Pharmacol Ther. 2018. PMID: 29130735 Free PMC article.
Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform.
Kozuka K, He Y, Koo-McCoy S, Kumaraswamy P, Nie B, Shaw K, Chan P, Leadbetter M, He L, Lewis JG, Zhong Z, Charmot D, Balaa M, King AJ, Caldwell JS, Siegel M. Kozuka K, et al. Among authors: king aj. Stem Cell Reports. 2017 Dec 12;9(6):1976-1990. doi: 10.1016/j.stemcr.2017.10.013. Epub 2017 Nov 16. Stem Cell Reports. 2017. PMID: 29153987 Free PMC article.
Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice.
Finn PD, Rodriguez D, Kohler J, Jiang Z, Wan S, Blanco E, King AJ, Chen T, Bell N, Dragoli D, Jacobs JW, Jain R, Leadbetter M, Siegel M, Carreras CW, Koo-McCoy S, Shaw K, Le C, Vanegas S, Hsu IH, Kozuka K, Okamoto K, Caldwell JS, Lewis JG. Finn PD, et al. Among authors: king aj. Am J Physiol Gastrointest Liver Physiol. 2019 Mar 1;316(3):G412-G424. doi: 10.1152/ajpgi.00300.2018. Epub 2019 Jan 3. Am J Physiol Gastrointest Liver Physiol. 2019. PMID: 30605011 Free PMC article.
NHE3 inhibitor tenapanor maintains intestinal barrier function, decreases visceral hypersensitivity, and attenuates TRPV1 signaling in colonic sensory neurons.
King AJ, Chang L, Li Q, Liu L, Zhu Y, Pasricha PJ, Wang J, Siegel M, Caldwell JS, Edelstein S, Rosenbaum DP, Kozuka K. King AJ, et al. Am J Physiol Gastrointest Liver Physiol. 2024 May 1;326(5):G543-G554. doi: 10.1152/ajpgi.00233.2023. Epub 2024 Jan 22. Am J Physiol Gastrointest Liver Physiol. 2024. PMID: 38252683 Free article.
Automatic Population of the Case Report Forms for an International Multifactorial Adaptive Platform Trial Amid the COVID-19 Pandemic.
King AJ, Higgins L, Au C, Malakouti S, Music E, Kalchthaler K, Clermont G, Garrard W, Huang DT, McVerry BJ, Seymour CW, Linstrum K, McNamara A, Green C, Loar I, Roberts T, Marroquin O, Angus DC, Horvat CM. King AJ, et al. AMIA Jt Summits Transl Sci Proc. 2024 May 31;2024:276-284. eCollection 2024. AMIA Jt Summits Transl Sci Proc. 2024. PMID: 38827056 Free PMC article.
Prevalence and Risk Factors for HPV Seropositivity and Anogenital DNA-Positivity among Men Who Have Sex With Men: A Repeated Cross-Sectional Study.
Kusters JM, Obels I, van der Klis FR, King AJ, Heijman T, Heijne JC, van Benthem BH, van der Loeff MFS; PASSYON study group. Kusters JM, et al. Among authors: king aj. Int J Infect Dis. 2024 May 20:107094. doi: 10.1016/j.ijid.2024.107094. Online ahead of print. Int J Infect Dis. 2024. PMID: 38777081 Free article.
862 results