Cross β-sheet conformation of keratin 8 is a specific feature of Mallory-Denk bodies compared with other hepatocyte inclusions.
Mahajan V, Klingstedt T, Simon R, Nilsson KP, Thueringer A, Kashofer K, Haybaeck J, Denk H, Abuja PM, Zatloukal K.
Mahajan V, et al. Among authors: denk h.
Gastroenterology. 2011 Sep;141(3):1080-1090.e1-7. doi: 10.1053/j.gastro.2011.05.039. Epub 2011 May 27.
Gastroenterology. 2011.
PMID: 21699779
BACKGROUND & AIMS: Mallory-Denk bodies (MDBs) are cytoplasmic protein aggregates in hepatocytes in steatohepatitis and other liver diseases. We investigated the molecular structure of keratin 8 (K8) and 18 (K18), sequestosome 1/p62, and ubiquitin, which are the major c …
BACKGROUND & AIMS: Mallory-Denk bodies (MDBs) are cytoplasmic protein aggregates in hepatocytes in steatohepatitis and other live …