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Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases.
Hahn J, Schauer C, Czegley C, Kling L, Petru L, Schmid B, Weidner D, Reinwald C, Biermann MHC, Blunder S, Ernst J, Lesner A, Bäuerle T, Palmisano R, Christiansen S, Herrmann M, Bozec A, Gruber R, Schett G, Hoffmann MH. Hahn J, et al. Among authors: hoffmann mh. FASEB J. 2019 Jan;33(1):1401-1414. doi: 10.1096/fj.201800752R. Epub 2018 Aug 21. FASEB J. 2019. PMID: 30130433 Free PMC article.
No evidence of pathogenic involvement of cathelicidins in patient cohorts and mouse models of lupus and arthritis.
Kienhöfer D, Hahn J, Schubert I, Reinwald C, Ipseiz N, Lang SC, Borràs ÈB, Amann K, Sjöwall C, Barron AE, Hueber AJ, Agerberth B, Schett G, Hoffmann MH. Kienhöfer D, et al. Among authors: hoffmann mh. PLoS One. 2014 Dec 23;9(12):e115474. doi: 10.1371/journal.pone.0115474. eCollection 2014. PLoS One. 2014. PMID: 25535966 Free PMC article.
Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis.
Leppkes M, Maueröder C, Hirth S, Nowecki S, Günther C, Billmeier U, Paulus S, Biermann M, Munoz LE, Hoffmann M, Wildner D, Croxford AL, Waisman A, Mowen K, Jenne DE, Krenn V, Mayerle J, Lerch MM, Schett G, Wirtz S, Neurath MF, Herrmann M, Becker C. Leppkes M, et al. Nat Commun. 2016 Mar 11;7:10973. doi: 10.1038/ncomms10973. Nat Commun. 2016. PMID: 26964500 Free PMC article.
Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation.
Muñoz LE, Bilyy R, Biermann MH, Kienhöfer D, Maueröder C, Hahn J, Brauner JM, Weidner D, Chen J, Scharin-Mehlmann M, Janko C, Friedrich RP, Mielenz D, Dumych T, Lootsik MD, Schauer C, Schett G, Hoffmann M, Zhao Y, Herrmann M. Muñoz LE, et al. Among authors: hoffmann m. Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):E5856-E5865. doi: 10.1073/pnas.1602230113. Epub 2016 Sep 19. Proc Natl Acad Sci U S A. 2016. PMID: 27647892 Free PMC article.
121 results