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Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.
González-Billalabeitia E, Seitzer N, Song SJ, Song MS, Patnaik A, Liu XS, Epping MT, Papa A, Hobbs RM, Chen M, Lunardi A, Ng C, Webster KA, Signoretti S, Loda M, Asara JM, Nardella C, Clohessy JG, Cantley LC, Pandolfi PP. González-Billalabeitia E, et al. Among authors: papa a. Cancer Discov. 2014 Aug;4(8):896-904. doi: 10.1158/2159-8290.CD-13-0230. Epub 2014 May 27. Cancer Discov. 2014. PMID: 24866151 Free PMC article.
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer.
Rodgers SJ, Ooms LM, Oorschot VMJ, Schittenhelm RB, Nguyen EV, Hamila SA, Rynkiewicz N, Gurung R, Eramo MJ, Sriratana A, Fedele CG, Caramia F, Loi S, Kerr G, Abud HE, Ramm G, Papa A, Ellisdon AM, Daly RJ, McLean CA, Mitchell CA. Rodgers SJ, et al. Among authors: papa a. Nat Commun. 2021 May 25;12(1):3140. doi: 10.1038/s41467-021-23241-6. Nat Commun. 2021. PMID: 34035258 Free PMC article.
PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis.
Srijakotre N, Liu HJ, Nobis M, Man J, Yip HYK, Papa A, Abud HE, Anderson KI, Welch HCE, Tiganis T, Timpson P, McLean CA, Ooms LM, Mitchell CA. Srijakotre N, et al. Among authors: papa a. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28056-28067. doi: 10.1073/pnas.2006445117. Epub 2020 Oct 23. Proc Natl Acad Sci U S A. 2020. PMID: 33097662 Free PMC article.
1,021 results