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In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy.
Wiederhold NP, Xu X, Wang A, Najvar LK, Garvey EP, Ottinger EA, Alimardanov A, Cradock J, Behnke M, Hoekstra WJ, Brand SR, Schotzinger RJ, Jaramillo R, Olivo M, Kirkpatrick WR, Patterson TF. Wiederhold NP, et al. Among authors: hoekstra wj. Antimicrob Agents Chemother. 2018 Oct 24;62(11):e01315-18. doi: 10.1128/AAC.01315-18. Print 2018 Nov. Antimicrob Agents Chemother. 2018. PMID: 30104280 Free PMC article.
Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong In Vitro Activity against Candida glabrata and C. krusei Isolates Clinically Resistant to Azole and Echinocandin Antifungal Compounds.
Schell WA, Jones AM, Garvey EP, Hoekstra WJ, Schotzinger RJ, Alexander BD. Schell WA, et al. Among authors: hoekstra wj. Antimicrob Agents Chemother. 2017 Feb 23;61(3):e01817-16. doi: 10.1128/AAC.01817-16. Print 2017 Mar. Antimicrob Agents Chemother. 2017. PMID: 27956419 Free PMC article.
Evaluation of VT-1161 for Treatment of Coccidioidomycosis in Murine Infection Models.
Shubitz LF, Trinh HT, Galgiani JN, Lewis ML, Fothergill AW, Wiederhold NP, Barker BM, Lewis ER, Doyle AL, Hoekstra WJ, Schotzinger RJ, Garvey EP. Shubitz LF, et al. Among authors: hoekstra wj. Antimicrob Agents Chemother. 2015 Dec;59(12):7249-54. doi: 10.1128/AAC.00593-15. Epub 2015 Sep 14. Antimicrob Agents Chemother. 2015. PMID: 26369964 Free PMC article.
VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection.
Gebremariam T, Wiederhold NP, Fothergill AW, Garvey EP, Hoekstra WJ, Schotzinger RJ, Patterson TF, Filler SG, Ibrahim AS. Gebremariam T, et al. Among authors: hoekstra wj. Antimicrob Agents Chemother. 2015 Dec;59(12):7815-7. doi: 10.1128/AAC.01437-15. Epub 2015 Sep 14. Antimicrob Agents Chemother. 2015. PMID: 26369977 Free PMC article.
The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii.
Lockhart SR, Fothergill AW, Iqbal N, Bolden CB, Grossman NT, Garvey EP, Brand SR, Hoekstra WJ, Schotzinger RJ, Ottinger E, Patterson TF, Wiederhold NP. Lockhart SR, et al. Among authors: hoekstra wj. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2528-31. doi: 10.1128/AAC.02770-15. Print 2016 Apr. Antimicrob Agents Chemother. 2016. PMID: 26787697 Free PMC article.
55 results