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Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis.
Phetsuksiri B, Jackson M, Scherman H, McNeil M, Besra GS, Baulard AR, Slayden RA, DeBarber AE, Barry CE 3rd, Baird MS, Crick DC, Brennan PJ. Phetsuksiri B, et al. Among authors: crick dc. J Biol Chem. 2003 Dec 26;278(52):53123-30. doi: 10.1074/jbc.M311209200. Epub 2003 Oct 14. J Biol Chem. 2003. PMID: 14559907 Free PMC article.
Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-{alpha}-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesis.
Huang H, Scherman MS, D'Haeze W, Vereecke D, Holsters M, Crick DC, McNeil MR. Huang H, et al. Among authors: crick dc. J Biol Chem. 2005 Jul 1;280(26):24539-43. doi: 10.1074/jbc.M504068200. Epub 2005 May 4. J Biol Chem. 2005. PMID: 15878857 Free article.
Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose.
Mikusová K, Huang H, Yagi T, Holsters M, Vereecke D, D'Haeze W, Scherman MS, Brennan PJ, McNeil MR, Crick DC. Mikusová K, et al. Among authors: crick dc. J Bacteriol. 2005 Dec;187(23):8020-5. doi: 10.1128/JB.187.23.8020-8025.2005. J Bacteriol. 2005. PMID: 16291675 Free PMC article.
129 results