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A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.
Paeshuyse J, Leyssen P, Mabery E, Boddeker N, Vrancken R, Froeyen M, Ansari IH, Dutartre H, Rozenski J, Gil LH, Letellier C, Lanford R, Canard B, Koenen F, Kerkhofs P, Donis RO, Herdewijn P, Watson J, De Clercq E, Puerstinger G, Neyts J. Paeshuyse J, et al. Among authors: neyts j. J Virol. 2006 Jan;80(1):149-60. doi: 10.1128/JVI.80.1.149-160.2006. J Virol. 2006. PMID: 16352539 Free PMC article.
The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication.
Paeshuyse J, Chezal JM, Froeyen M, Leyssen P, Dutartre H, Vrancken R, Canard B, Letellier C, Li T, Mittendorfer H, Koenen F, Kerkhofs P, De Clercq E, Herdewijn P, Puerstinger G, Gueiffier A, Chavignon O, Teulade JC, Neyts J. Paeshuyse J, et al. Among authors: neyts j. J Virol. 2007 Oct;81(20):11046-53. doi: 10.1128/JVI.00388-07. Epub 2007 Aug 8. J Virol. 2007. PMID: 17686854 Free PMC article.
Molecular strategies to inhibit the replication of RNA viruses.
Leyssen P, De Clercq E, Neyts J. Leyssen P, et al. Among authors: neyts j. Antiviral Res. 2008 Apr;78(1):9-25. doi: 10.1016/j.antiviral.2008.01.004. Epub 2008 Feb 4. Antiviral Res. 2008. PMID: 18313769 Free PMC article. Review.
Potential use of antiviral agents in polio eradication.
De Palma AM, Pürstinger G, Wimmer E, Patick AK, Andries K, Rombaut B, De Clercq E, Neyts J. De Palma AM, et al. Among authors: neyts j. Emerg Infect Dis. 2008 Apr;14(4):545-51. doi: 10.3201/eid1404.070439. Emerg Infect Dis. 2008. PMID: 18394270 Free PMC article.
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.
Paeshuyse J, Letellier C, Froeyen M, Dutartre H, Vrancken R, Canard B, De Clercq E, Gueiffier A, Teulade JC, Herdewijn P, Puerstinger G, Koenen F, Kerkhofs P, Baraldi PG, Neyts J. Paeshuyse J, et al. Among authors: neyts j. Antiviral Res. 2009 Jun;82(3):141-7. doi: 10.1016/j.antiviral.2009.02.192. Epub 2009 Feb 27. Antiviral Res. 2009. PMID: 19428605
Structure and functionality in flavivirus NS-proteins: perspectives for drug design.
Bollati M, Alvarez K, Assenberg R, Baronti C, Canard B, Cook S, Coutard B, Decroly E, de Lamballerie X, Gould EA, Grard G, Grimes JM, Hilgenfeld R, Jansson AM, Malet H, Mancini EJ, Mastrangelo E, Mattevi A, Milani M, Moureau G, Neyts J, Owens RJ, Ren J, Selisko B, Speroni S, Steuber H, Stuart DI, Unge T, Bolognesi M. Bollati M, et al. Among authors: neyts j. Antiviral Res. 2010 Aug;87(2):125-48. doi: 10.1016/j.antiviral.2009.11.009. Epub 2009 Nov 27. Antiviral Res. 2010. PMID: 19945487 Free PMC article. Review.
662 results