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PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359.
Rodriguez J, Herrero A, Li S, Rauch N, Quintanilla A, Wynne K, Krstic A, Acosta JC, Taylor C, Schlisio S, von Kriegsheim A. Rodriguez J, et al. Among authors: taylor c. Cell Rep. 2018 Jul 31;24(5):1316-1329. doi: 10.1016/j.celrep.2018.06.108. Cell Rep. 2018. PMID: 30067985 Free PMC article.
A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network.
Nguyen LK, Cavadas MA, Scholz CC, Fitzpatrick SF, Bruning U, Cummins EP, Tambuwala MM, Manresa MC, Kholodenko BN, Taylor CT, Cheong A. Nguyen LK, et al. Among authors: taylor ct. J Cell Sci. 2013 Mar 15;126(Pt 6):1454-63. doi: 10.1242/jcs.119974. Epub 2013 Feb 6. J Cell Sci. 2013. PMID: 23390316
Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.
Scholz CC, Cavadas MA, Tambuwala MM, Hams E, Rodríguez J, von Kriegsheim A, Cotter P, Bruning U, Fallon PG, Cheong A, Cummins EP, Taylor CT. Scholz CC, et al. Among authors: taylor ct. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18490-5. doi: 10.1073/pnas.1309718110. Epub 2013 Oct 21. Proc Natl Acad Sci U S A. 2013. PMID: 24145445 Free PMC article.
FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.
Scholz CC, Rodriguez J, Pickel C, Burr S, Fabrizio JA, Nolan KA, Spielmann P, Cavadas MA, Crifo B, Halligan DN, Nathan JA, Peet DJ, Wenger RH, Von Kriegsheim A, Cummins EP, Taylor CT. Scholz CC, et al. Among authors: taylor ct. PLoS Biol. 2016 Jan 11;14(1):e1002347. doi: 10.1371/journal.pbio.1002347. eCollection 2016 Jan. PLoS Biol. 2016. PMID: 26752685 Free PMC article.
Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner.
Fitzpatrick SF, Fábián Z, Schaible B, Lenihan CR, Schwarzl T, Rodriguez J, Zheng X, Li Z, Tambuwala MM, Higgins DG, O'Meara Y, Slattery C, Manresa MC, Fraisl P, Bruning U, Baes M, Carmeliet P, Doherty G, von Kriegsheim A, Cummins EP, Taylor CT. Fitzpatrick SF, et al. Among authors: taylor ct. Biochem Biophys Res Commun. 2016 Jun 3;474(3):579-586. doi: 10.1016/j.bbrc.2016.04.085. Epub 2016 Apr 27. Biochem Biophys Res Commun. 2016. PMID: 27130823 Free article.
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.
Cummins EP, Berra E, Comerford KM, Ginouves A, Fitzgerald KT, Seeballuck F, Godson C, Nielsen JE, Moynagh P, Pouyssegur J, Taylor CT. Cummins EP, et al. Among authors: taylor ct. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18154-9. doi: 10.1073/pnas.0602235103. Epub 2006 Nov 17. Proc Natl Acad Sci U S A. 2006. PMID: 17114296 Free PMC article.
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function.
Tambuwala MM, Cummins EP, Lenihan CR, Kiss J, Stauch M, Scholz CC, Fraisl P, Lasitschka F, Mollenhauer M, Saunders SP, Maxwell PH, Carmeliet P, Fallon PG, Schneider M, Taylor CT. Tambuwala MM, et al. Among authors: taylor ct. Gastroenterology. 2010 Dec;139(6):2093-101. doi: 10.1053/j.gastro.2010.06.068. Epub 2010 Jun 30. Gastroenterology. 2010. PMID: 20600011
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.
Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW, Ratcliffe PJ, Maxwell PH, Carmeliet P, Whyte MK. Walmsley SR, et al. Among authors: taylor ct. J Clin Invest. 2011 Mar;121(3):1053-63. doi: 10.1172/JCI43273. Epub 2011 Feb 7. J Clin Invest. 2011. PMID: 21317538 Free PMC article.
7,736 results