Yang DH - Search Results

1

Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds.

Gong GQ, Wang K, Dai XC, Zhou Y, Basnet R, Chen Y, Yang DH, Lee WJ, Buchanan CM, Flanagan JU, Shepherd PR, Chen Y, Wang MW. Gong GQ, et al. Among authors: yang dh. Acta Pharmacol Sin. 2018 Dec;39(12):1902-1912. doi: 10.1038/s41401-018-0087-6. Epub 2018 Jul 23. Acta Pharmacol Sin. 2018. PMID: 30038340 Free PMC article.

2

High-throughput screening for GPR119 modulators identifies a novel compound with anti-diabetic efficacy in db/db mice.

Zhang M, Feng Y, Wang J, Zhao J, Li T, He M, Yang D, Nosjean O, Boutin J, Renard P, Wang MW. Zhang M, et al. PLoS One. 2013 May 21;8(5):e63861. doi: 10.1371/journal.pone.0063861. Print 2013. PLoS One. 2013. PMID: 23704946 Free PMC article.

3

The putative signal peptide of glucagon-like peptide-1 receptor is not required for receptor synthesis but promotes receptor expression.

Ge Y, Yang D, Dai A, Zhou C, Zhu Y, Wang MW. Ge Y, et al. Biosci Rep. 2014 Nov 21;34(6):e00152. doi: 10.1042/BSR20140120. Biosci Rep. 2014. PMID: 25330813 Free PMC article.

4

Conformational states of the full-length glucagon receptor.

Yang L, Yang D, de Graaf C, Moeller A, West GM, Dharmarajan V, Wang C, Siu FY, Song G, Reedtz-Runge S, Pascal BD, Wu B, Potter CS, Zhou H, Griffin PR, Carragher B, Yang H, Wang MW, Stevens RC, Jiang H. Yang L, et al. Nat Commun. 2015 Jul 31;6:7859. doi: 10.1038/ncomms8859. Nat Commun. 2015. PMID: 26227798 Free PMC article.

5

Landmark studies on the glucagon subfamily of GPCRs: from small molecule modulators to a crystal structure.

Yang DH, Zhou CH, Liu Q, Wang MW. Yang DH, et al. Acta Pharmacol Sin. 2015 Sep;36(9):1033-42. doi: 10.1038/aps.2015.78. Epub 2015 Aug 17. Acta Pharmacol Sin. 2015. PMID: 26279155 Free PMC article. Review.

6

Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R).

Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW. Yang D, et al. J Biol Chem. 2016 Jun 17;291(25):12991-3004. doi: 10.1074/jbc.M116.721977. Epub 2016 Apr 8. J Biol Chem. 2016. PMID: 27059958 Free PMC article.

7

Design, synthesis, structure-activity relationships, and docking studies of pyrazole-containing derivatives as a novel series of potent glucagon receptor antagonists.

Shu S, Cai X, Li J, Feng Y, Dai A, Wang J, Yang D, Wang MW, Liu H. Shu S, et al. Bioorg Med Chem. 2016 Jun 15;24(12):2852-63. doi: 10.1016/j.bmc.2016.04.053. Epub 2016 Apr 26. Bioorg Med Chem. 2016. PMID: 27161876

8

Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors.

Zhao LH, Yin Y, Yang D, Liu B, Hou L, Wang X, Pal K, Jiang Y, Feng Y, Cai X, Dai A, Liu M, Wang MW, Melcher K, Xu HE. Zhao LH, et al. J Biol Chem. 2016 Jul 15;291(29):15119-30. doi: 10.1074/jbc.M116.726620. Epub 2016 May 13. J Biol Chem. 2016. PMID: 27226600 Free PMC article.

9

Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes.

Graaf Cd, Donnelly D, Wootten D, Lau J, Sexton PM, Miller LJ, Ahn JM, Liao J, Fletcher MM, Yang D, Brown AJ, Zhou C, Deng J, Wang MW. Graaf Cd, et al. Pharmacol Rev. 2016 Oct;68(4):954-1013. doi: 10.1124/pr.115.011395. Pharmacol Rev. 2016. PMID: 27630114 Free PMC article. Review.

10

A historic study that opened a new chapter in nutritional science.

Lei SF, Yang DH, Wang MW. Lei SF, et al. Among authors: yang dh. Acta Pharmacol Sin. 2016 Dec;37(12):1641-1644. doi: 10.1038/aps.2016.131. Epub 2016 Nov 21. Acta Pharmacol Sin. 2016. PMID: 27867188 Free PMC article. No abstract available.

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