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Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2 Type X (sPLA2-X) Inhibitors.
Knerr L, Giordanetto F, Nordberg P, Pettersen D, Selmi N, Beisel HG, de la Motte H, Olsson T, Perkins TDJ, Herslöf M, Månsson Å, Dahlström M, Starke I, Broddefalk J, Saarinen G, Klingegård F, Hurt-Camejo E, Rosengren B, Brengdahl J, Jansen F, Rohman M, Sandmark J, Hallberg K, Åkerud T, Roth RG, Ahlqvist M. Knerr L, et al. Among authors: herslof m. ACS Med Chem Lett. 2018 Jun 23;9(7):594-599. doi: 10.1021/acsmedchemlett.7b00505. eCollection 2018 Jul 12. ACS Med Chem Lett. 2018. PMID: 30034585 Free PMC article.
Discovery of AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP) for the treatment of inflammatory diseases.
Lemurell M, Ulander J, Winiwarter S, Dahlén A, Davidsson Ö, Emtenäs H, Broddefalk J, Swanson M, Hovdal D, Plowright AT, Pettersen A, Rydén-Landergren M, Barlind J, Llinas A, Herslöf M, Drmota T, Sigfridsson K, Moses S, Whatling C. Lemurell M, et al. Among authors: herslof m. J Med Chem. 2015 Jan 22;58(2):897-911. doi: 10.1021/jm501531v. Epub 2014 Dec 22. J Med Chem. 2015. PMID: 25478788
Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function.
Sandmark J, Tigerström A, Akerud T, Althage M, Antonsson T, Blaho S, Bodin C, Boström J, Chen Y, Dahlén A, Eriksson PO, Evertsson E, Fex T, Fjellström O, Gustafsson D, Herslöf M, Hicks R, Jarkvist E, Johansson C, Kalies I, Karlsson Svalstedt B, Kartberg F, Legnehed A, Martinsson S, Moberg A, Ridderström M, Rosengren B, Sabirsh A, Thelin A, Vinblad J, Wellner AU, Xu B, Östlund-Lindqvist AM, Knecht W. Sandmark J, et al. Among authors: herslof m. J Biol Chem. 2020 Apr 10;295(15):5136-5151. doi: 10.1074/jbc.RA119.011251. Epub 2020 Mar 4. J Biol Chem. 2020. PMID: 32132173 Free PMC article.
Solid phase synthesis of diamides as potential bone resorption inhibitors.
Edvinsson KM, Herslöf M, Holm P, Kann N, Keeling DJ, Mattsson JP, Nordén B, Shcherbukhin V. Edvinsson KM, et al. Among authors: herslof m. Bioorg Med Chem Lett. 2000 Mar 6;10(5):503-7. doi: 10.1016/s0960-894x(00)00025-1. Bioorg Med Chem Lett. 2000. PMID: 10743958
Tissue-selective inhibition of vacuolar acid pumps.
Keeling DJ, Herslöf M, Mattsson JP, Ryberg B. Keeling DJ, et al. Among authors: herslof m. Acta Physiol Scand Suppl. 1998 Aug;643:195-201. Acta Physiol Scand Suppl. 1998. PMID: 9789561 No abstract available.
Vacuolar H(+)-ATPases. Targets for drug discovery?
Keeling DJ, Herslöf M, Ryberg B, Sjögren S, Sölvell L. Keeling DJ, et al. Among authors: herslof m. Ann N Y Acad Sci. 1997 Nov 3;834:600-8. doi: 10.1111/j.1749-6632.1997.tb52329.x. Ann N Y Acad Sci. 1997. PMID: 9405871 Review. No abstract available.
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