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Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.
Dev H, Chiang TW, Lescale C, de Krijger I, Martin AG, Pilger D, Coates J, Sczaniecka-Clift M, Wei W, Ostermaier M, Herzog M, Lam J, Shea A, Demir M, Wu Q, Yang F, Fu B, Lai Z, Balmus G, Belotserkovskaya R, Serra V, O'Connor MJ, Bruna A, Beli P, Pellegrini L, Caldas C, Deriano L, Jacobs JJL, Galanty Y, Jackson SP. Dev H, et al. Among authors: jacobs jjl. Nat Cell Biol. 2018 Aug;20(8):954-965. doi: 10.1038/s41556-018-0140-1. Epub 2018 Jul 18. Nat Cell Biol. 2018. PMID: 30022119 Free PMC article.
Senescence: back to telomeres.
Jacobs JJ. Jacobs JJ. Nat Rev Mol Cell Biol. 2013 Apr;14(4):196. Nat Rev Mol Cell Biol. 2013. PMID: 23847780 No abstract available.
The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.
Barazas M, Annunziato S, Pettitt SJ, de Krijger I, Ghezraoui H, Roobol SJ, Lutz C, Frankum J, Song FF, Brough R, Evers B, Gogola E, Bhin J, van de Ven M, van Gent DC, Jacobs JJL, Chapman R, Lord CJ, Jonkers J, Rottenberg S. Barazas M, et al. Among authors: jacobs jjl. Cell Rep. 2018 May 15;23(7):2107-2118. doi: 10.1016/j.celrep.2018.04.046. Cell Rep. 2018. PMID: 29768208 Free PMC article.
REV7: Jack of many trades.
de Krijger I, Boersma V, Jacobs JJL. de Krijger I, et al. Among authors: jacobs jjl. Trends Cell Biol. 2021 Aug;31(8):686-701. doi: 10.1016/j.tcb.2021.04.002. Epub 2021 May 4. Trends Cell Biol. 2021. PMID: 33962851 Free PMC article. Review.
MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair.
de Krijger I, Föhr B, Pérez SH, Vincendeau E, Serrat J, Thouin AM, Susvirkar V, Lescale C, Paniagua I, Hoekman L, Kaur S, Altelaar M, Deriano L, Faesen AC, Jacobs JJL. de Krijger I, et al. Among authors: jacobs jjl. Nat Commun. 2021 Sep 14;12(1):5421. doi: 10.1038/s41467-021-25724-y. Nat Commun. 2021. PMID: 34521823 Free PMC article.
71 results