Fillgrove KL - Search Results

1

Extended-Duration MK-8591-Eluting Implant as a Candidate for HIV Treatment and Prevention.

Barrett SE, Teller RS, Forster SP, Li L, Mackey MA, Skomski D, Yang Z, Fillgrove KL, Doto GJ, Wood SL, Lebron J, Grobler JA, Sanchez RI, Liu Z, Lu B, Niu T, Sun L, Gindy ME. Barrett SE, et al. Among authors: fillgrove kl. Antimicrob Agents Chemother. 2018 Sep 24;62(10):e01058-18. doi: 10.1128/AAC.01058-18. Print 2018 Oct. Antimicrob Agents Chemother. 2018. PMID: 30012772 Free PMC article.

2

Characterisation of the absorption, distribution, metabolism, excretion and mass balance of doravirine, a non-nucleoside reverse transcriptase inhibitor in humans.

Sanchez RI, Fillgrove KL, Yee KL, Liang Y, Lu B, Tatavarti A, Liu R, Anderson MS, Behm MO, Fan L, Li Y, Butterton JR, Iwamoto M, Khalilieh SG. Sanchez RI, et al. Among authors: fillgrove kl. Xenobiotica. 2019 Apr;49(4):422-432. doi: 10.1080/00498254.2018.1451667. Epub 2018 Mar 28. Xenobiotica. 2019. PMID: 29557716 Clinical Trial.

3

Synthesis and Antiviral Evaluation of Carbocyclic Nucleoside Analogs of Nucleoside Reverse Transcriptase Translocation Inhibitor MK-8591 (4'-Ethynyl-2-fluoro-2'-deoxyadenosine).

Alexandre FR, Rahali R, Rahali H, Guillon S, Convard T, Fillgrove K, Lai MT, Meillon JC, Xu M, Small J, Dousson CB, Raheem IT. Alexandre FR, et al. J Med Chem. 2018 Oct 25;61(20):9218-9228. doi: 10.1021/acs.jmedchem.8b00141. Epub 2018 Oct 12. J Med Chem. 2018. PMID: 30265808

4

In Vitro Evaluation of the Drug Interaction Potential of Doravirine.

Bleasby K, Fillgrove KL, Houle R, Lu B, Palamanda J, Newton DJ, Lin M, Chan GH, Sanchez RI. Bleasby K, et al. Among authors: fillgrove kl. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02492-18. doi: 10.1128/AAC.02492-18. Print 2019 Apr. Antimicrob Agents Chemother. 2019. PMID: 30745395 Free PMC article.

5

Toward highly sensitive and reproducible LC-MS/MS analysis of MK-8591 phosphorylated anabolites in human peripheral blood mononuclear cells.

Sun L, Chavez-Eng C, Fillgrove KL, Lu B, Xie I, Rudd DJ, Breidinger S, Anderson M, Yeh S, Zhang R, Woolf EJ. Sun L, et al. Among authors: fillgrove kl. Bioanalysis. 2019 Feb;11(4):233-250. doi: 10.4155/bio-2018-0101. Epub 2019 Feb 15. Bioanalysis. 2019. PMID: 30767560

6

Once-Weekly Oral Dosing of MK-8591 Protects Male Rhesus Macaques From Intrarectal Challenge With SHIV109CP3.

Markowitz M, Gettie A, St Bernard L, Andrews CD, Mohri H, Horowitz A, Grasperge BF, Blanchard JL, Niu T, Sun L, Fillgrove K, Hazuda DJ, Grobler JA. Markowitz M, et al. J Infect Dis. 2020 Apr 7;221(9):1398-1406. doi: 10.1093/infdis/jiz271. J Infect Dis. 2020. PMID: 31175822

7

Physiologically Based Pharmacokinetic Modeling of Doravirine and Its Major Metabolite to Support Dose Adjustment With Rifabutin.

Yee KL, Cabalu TD, Kuo Y, Fillgrove KL, Liu Y, Triantafyllou I, McClain S, Dreyer D, Wenning L, Stoch SA, Iwamoto M, Sanchez RI, Khalilieh SG. Yee KL, et al. Among authors: fillgrove kl. J Clin Pharmacol. 2021 Mar;61(3):394-405. doi: 10.1002/jcph.1747. Epub 2020 Sep 28. J Clin Pharmacol. 2021. PMID: 32989795 Clinical Trial.

8

Islatravir Is Not Expected to Be a Victim or Perpetrator of Drug-Drug Interactions via Major Drug-Metabolizing Enzymes or Transporters.

Bleasby K, Houle R, Hafey M, Lin M, Guo J, Lu B, Sanchez RI, Fillgrove KL. Bleasby K, et al. Among authors: fillgrove kl. Viruses. 2021 Aug 7;13(8):1566. doi: 10.3390/v13081566. Viruses. 2021. PMID: 34452431 Free PMC article.

9

Safety and Pharmacokinetics of Once-Daily Multiple-Dose Administration of Islatravir in Adults Without HIV.

Matthews RP, Jackson Rudd D, Zhang S, Fillgrove KL, Sterling LM, Grobler JA, Vargo RC, Stoch SA, Iwamoto M. Matthews RP, et al. Among authors: fillgrove kl. J Acquir Immune Defic Syndr. 2021 Nov 1;88(3):314-321. doi: 10.1097/QAI.0000000000002755. J Acquir Immune Defic Syndr. 2021. PMID: 34651606 Clinical Trial.

10

A Phase 1 Study to Evaluate the Drug Interaction Between Islatravir (MK-8591) and Doravirine in Adults Without HIV.

Matthews RP, Jackson Rudd D, Fillgrove KL, Zhang S, Tomek C, Stoch SA, Iwamoto M. Matthews RP, et al. Among authors: fillgrove kl. Clin Drug Investig. 2021 Jul;41(7):629-638. doi: 10.1007/s40261-021-01046-1. Epub 2021 Jun 21. Clin Drug Investig. 2021. PMID: 34151413 Free PMC article. Clinical Trial.

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