Zinzalla G - Search Results

1

A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation.

Castell A, Yan Q, Fawkner K, Hydbring P, Zhang F, Verschut V, Franco M, Zakaria SM, Bazzar W, Goodwin J, Zinzalla G, Larsson LG. Castell A, et al. Among authors: zinzalla g. Sci Rep. 2018 Jul 3;8(1):10064. doi: 10.1038/s41598-018-28107-4. Sci Rep. 2018. PMID: 29968736 Free PMC article.

2

The structure of INI1/hSNF5 RPT1 and its interactions with the c-MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex.

Sammak S, Allen MD, Hamdani N, Bycroft M, Zinzalla G. Sammak S, et al. Among authors: zinzalla g. FEBS J. 2018 Nov;285(22):4165-4180. doi: 10.1111/febs.14660. Epub 2018 Oct 1. FEBS J. 2018. PMID: 30222246 Free PMC article.

3

Biophysical and Structural Methods to Study the bHLHZip Region of Human c-MYC.

Zinzalla G. Zinzalla G. Methods Mol Biol. 2021;2318:21-43. doi: 10.1007/978-1-0716-1476-1_3. Methods Mol Biol. 2021. PMID: 34019285

4

Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA.

Sammak S, Hamdani N, Gorrec F, Allen MD, Freund SMV, Bycroft M, Zinzalla G. Sammak S, et al. Among authors: zinzalla g. Biochemistry. 2019 Jul 23;58(29):3144-3154. doi: 10.1021/acs.biochem.9b00296. Epub 2019 Jul 11. Biochemistry. 2019. PMID: 31260268 Free PMC article.

5

Targeting protein-protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs).

Sammak S, Zinzalla G. Sammak S, et al. Among authors: zinzalla g. Prog Biophys Mol Biol. 2015 Oct;119(1):41-6. doi: 10.1016/j.pbiomolbio.2015.06.004. Epub 2015 Jun 27. Prog Biophys Mol Biol. 2015. PMID: 26126425 Review.

6

Paving the way to targeting HECT ubiquitin ligases.

Zinzalla G. Zinzalla G. Future Med Chem. 2015;7(16):2107-11. doi: 10.4155/fmc.15.141. Epub 2015 Oct 29. Future Med Chem. 2015. PMID: 26510616 No abstract available.

7

Targeting MYC: is it getting any easier?

Zinzalla G. Zinzalla G. Future Med Chem. 2016 Oct;8(16):1899-1902. doi: 10.4155/fmc-2016-0119. Epub 2016 Sep 21. Future Med Chem. 2016. PMID: 27652613 Free article. No abstract available.

8

A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex.

Zinzalla G. Zinzalla G. Chembiochem. 2016 Apr 15;17(8):677-82. doi: 10.1002/cbic.201500565. Epub 2016 Jan 28. Chembiochem. 2016. PMID: 26684344

9

SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site.

Allen MD, Freund SMV, Bycroft M, Zinzalla G. Allen MD, et al. Among authors: zinzalla g. Commun Biol. 2021 May 5;4(1):528. doi: 10.1038/s42003-021-02050-z. Commun Biol. 2021. PMID: 33953332 Free PMC article.

10

Structure of the BRK domain of the SWI/SNF chromatin remodeling complex subunit BRG1 reveals a potential role in protein-protein interactions.

Allen MD, Bycroft M, Zinzalla G. Allen MD, et al. Among authors: zinzalla g. Protein Sci. 2020 Apr;29(4):1047-1053. doi: 10.1002/pro.3820. Epub 2020 Jan 13. Protein Sci. 2020. PMID: 31909846 Free PMC article.

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