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Human histone demethylase KDM6B can catalyse sequential oxidations.
Hopkinson RJ , Langley GW , Belle R , Walport LJ , Dunne K , Münzel M , Salah E , Kawamura A , Claridge TDW , Schofield CJ . Hopkinson RJ , et al. Among authors: walport lj. Chem Commun (Camb). 2018 Jul 12;54(57):7975-7978. doi: 10.1039/c8cc04057e. Chem Commun (Camb). 2018. PMID: 29961803 Free PMC article.
Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.
Woon EC, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JH, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, Oppermann U, McDonough MA, Schofield CJ. Woon EC, et al. Among authors: walport lj. Angew Chem Int Ed Engl. 2012 Feb 13;51(7):1631-4. doi: 10.1002/anie.201107833. Epub 2012 Jan 12. Angew Chem Int Ed Engl. 2012. PMID: 22241642 No abstract available.
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, Strain-Damerell C, Gileadi C, Kochan G, Leung IK, Dunford J, Yeoh KK, Ratcliffe PJ, Burgess-Brown N, von Delft F, Muller S, Marsden B, Brennan PE, McDonough MA, Oppermann U, Klose RJ, Schofield CJ, Kawamura A. Rose NR, et al. Among authors: walport lj. J Med Chem. 2012 Jul 26;55(14):6639-43. doi: 10.1021/jm300677j. Epub 2012 Jul 11. J Med Chem. 2012. PMID: 22724510 Free PMC article.
Mechanisms of human histone and nucleic acid demethylases.
Walport LJ, Hopkinson RJ, Schofield CJ. Walport LJ, et al. Curr Opin Chem Biol. 2012 Dec;16(5-6):525-34. doi: 10.1016/j.cbpa.2012.09.015. Epub 2012 Oct 10. Curr Opin Chem Biol. 2012. PMID: 23063108 Review.
Is JmjC oxygenase catalysis limited to demethylation?
Hopkinson RJ, Walport LJ, Münzel M, Rose NR, Smart TJ, Kawamura A, Claridge TD, Schofield CJ. Hopkinson RJ, et al. Among authors: walport lj. Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7709-13. doi: 10.1002/anie.201303282. Epub 2013 Jun 20. Angew Chem Int Ed Engl. 2013. PMID: 23788451 Free PMC article.
Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.
Walport LJ, Hopkinson RJ, Vollmar M, Madden SK, Gileadi C, Oppermann U, Schofield CJ, Johansson C. Walport LJ, et al. J Biol Chem. 2014 Jun 27;289(26):18302-13. doi: 10.1074/jbc.M114.555052. Epub 2014 May 5. J Biol Chem. 2014. PMID: 24798337 Free PMC article.
Epigenetic regulation by histone demethylases in hypoxia.
Hancock RL, Dunne K, Walport LJ, Flashman E, Kawamura A. Hancock RL, et al. Among authors: walport lj. Epigenomics. 2015 Aug;7(5):791-811. doi: 10.2217/epi.15.24. Epub 2015 Apr 2. Epigenomics. 2015. PMID: 25832587 Free article. Review.
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